I know this is a well known issue among the community, but I wanted to report that AI pathing is still a problem even early game. I only just progressed to making Cloudy Meth and even before doing so, with only 6-8 tiles of Factory land unlocked (60% used), all Cleaners and Engineers aren't functioning as well as they should. Lots of broken items, and most of the factory is now filthy. Other cleaners/engineers elsewhere are fine. The ones at the factory mostly stand around now 'looking for work' on repeat. Regular workers are beginning to starve or have unmet hygiene needs, etc, despite ample access and ample breaks.

I've tried:
Saving and Reloading (used to work)
Reassigning rooms and hours
Firing and Hiring replacements
Demolishing and Rebuilding areas
Replacing broken items manually
Playing on slowest speed, changing speeds

This is definitely breaking my game and I'm not really wanting to start over. If anyone has any other suggestions, let me know! I'd be happy to send a save file if requested.