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get 8 of them, add a dozen orso oxygen fuses to them and set up autocrafters to spam oxygen rockets.
more in genral since fuses affect 8 machines, having 8 of all the machines is a good idea.
Then 5 of every T3 machines (drills, heater, tree spreader) with fuses of course. The speed is nice. Oh and the stacking mod comes in handy with this.
This is for dna. Then set up 8 animal shelters and start launching animal rockets. Last save I had launched 400 rockets just using up bee larva.
But when I really want things to pick up, it's fuses that do the trick for me. Each set of three fuses can accelerate up to 8 machines - sometimes it can be a bit tricky getting them all in reach, but then again, you don't always need 8 of each anyways.. often 3, 4, or 5 of any given machine does the trick nicely, assuming, of course, that I've used the proper fuses to accelerate them, lol!
In the end what you get out of it all really depends on the machines themselves and their basic output - and the balance in your game, of course! :-)
2. Optimizers with fuses.
Every rocket give you at least +1000% bonus.
Every fuse (except power) give +500% bonus to nearest machines.
After that, you won't need many machines. 4-5 T5 drills and heaters, buffed by rockets and fuses, increase Ti quite quickly.
Same with organics. You don't need a lot of feeders, hives, etc. Quality over quantity. Fuses and rockets accelerate Ti bonuses to huge values. One T2 machine optimizer with 3 fuses and 1 T3 tree spreader more effective than 15 T3 spreaders (because 1500% bonus). You can use two T2 optimizers for 3000% bonus etc.
You can buy fuses from trade rocket, they are quite cheap (except for energy ones). T1 rockets also very cheap and available in early stages of game.