OS: Windows 10 LTSC 2021

Problem: The game hangs the pc when I click on a skill on the skills book or other random situations like the start of a new mission, the only way to unfreeze the pc was to alt-tab back to desktop and then click the game icon on the task bar to resume the game (for multiple times).

To fix this issue, I extracted and put VXDK's DLLs into the game's "bin" folder (to reach that you need to click 'browse local files' by right-clicking the game on your steam library).
To download the files you need to download the latest release from https://github.com/doitsujin/dxvk/releases/ , extract the archive with an appropriate program such as 7-Zip, and copy the DLLs inside the x64 fonder into the game's bin folder.
Now the game doesn't freeze anymore. (modificato)