Desktop with Win 10, AMD CPU, and nVidia GPU.

I have tried all the registry tricks (Hardware Performance, Windowed mode, Controller, etc.), C++ redistributables / PhysX / DirectX re-installs, and changing desktop resolution for good measure.

The only thing that changes anything at all is Win7/8 compatibility. With it the game runs but throws a C++ R6025 error "Pure virtual function call", and when I close the error message the game closes too.

Is there anything else I can do or should I just forget about the game?