verify game files

check your drivers are up to date

game doesn't crash for me even when using all DLC in the same mission

Maybe try reinstalling the game. That shouldn't be happening.

Hey Tizzitch,
If none of the suggestions made by Kunovega or ezwip solve the issue, please send a message to our support at support@kalypsomedia.com with a description of the issue, a DxDiag.txt and a crash dump attached, so we can investigate for you!
To create a DxDiag.txt, please do the following:

• Click "Start" button and choose "Run". Or alternatively, press (Windows-Button)+R
  
• Then type "dxdiag" (without quotation marks) and click “OK”
  
• Click the "Save all Information"-button, located at the bottom of the program window
  
• Save the file as "dxdiag.txt”
  
• Attach the file "dxdiag.txt" to your email to support@kalypsomedia.com

You can find the crash dump here:

• Windows: %USERPROFILE%/My Documents/My Games/Tropico6/Saved/Crashes
  
• Linux:$XDG_DATA_HOME/Tropico6/Saved/Crashes
  
• Linux (logs): $XDG_DATA_HOME/Tropico6/Saved/Logs
  
• MacOS. $XDG_DATA_HOME/Tropico6/Saved/Crashes

Our support will get back to you as soon as possible.
Have a good one!