Originally posted by Jackeea:

This is an incredibly OP and gamebreaking modification to make that makes most of the game trivial...

That being said, go to C:\Program Files (x86)\Steam\steamapps\workshop\content\262060 , then find the mod that you want to edit. Then, go to "trinkets", and look in the files there.

For example, a Shrieker trinket looks like:

{ "id" : "crow_wingfeather", "buffs" : [ "TRINKET_CROW_WINGFEATHER_BUFF", "TRINKET_CROW_DISEASERESIST_BUFF", "TRINKET_CROW_WINGFEATHER_BUFF2", "TRINKET_CROW_STRESS_DEBUFF" ], "hero_class_requirements": [ ], "rarity" : "crow", "price" : 1, "limit" : 1, "origin_dungeon" : "" },

Remove "TRINKET_CROW_STRESS_DEBUFF" and that'll take off the debuffs from that trinket. Other trinkets should have similar lines; remove the ones that cause debuffs and you're done.