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The Boomer is a Special Infected that vomits a special bile at Survivors, which temporarily blinds them and draws a Horde of Common Infected to them. At a distance the Boomer isn't much of a threat; their large size and low health make them an easy target against any weapon at mid or long range. However, if within range, they can vomit on Survivors, attracting the Horde.

When they die, they explode, covering any Survivors who are close enough with bile, blinding them and causing them to stumble backwards. The Boomer is notorious on the Expert difficulty for being able to snipe Survivors. Boomers can be anticipated because of the near-constant gurgling they make. In Left 4 Dead 2, there is also a female Boomer, although the gender has no effect on gameplay.
The Hunter is a Special Infected that has the least visible mutations, and can be mistaken for a Common Infected. The Hunter is extremely fast and agile, capable of quickly scaling walls. Additionally, he can pounce and pin down Survivors, clawing at their abdomen until either the victim is dead or the Hunter has been knocked off or killed by another Survivor. Hunters are not the most physically robust Infected, having relatively low health, and thus it doesn't take very much to kill them.

When the Hunter crouches down in preparation to pounce, he growls, giving himself away to any nearby Survivors. However, whilst standing, he makes no noise. The Hunter is the only Special Infected that can remain absolutely silent. In Left 4 Dead 2, they can be killed with a melee weapon while in the state of pouncing by aiming upwards and hitting, although this is fairly difficult, as timing is vital and it's easier to kill them from a distance with a high-powered primary weapon.

The Spitter is a Special Infected in Left 4 Dead 2. She possesses the ability to spit a green ball of acid from long distances, which, upon hitting the ground, will expand into a large puddle and damage any Survivors who make contact with it. After spitting, however, the Spitter is temporarily paralyzed for a second, giving the Survivors a chance to kill her. The Spitter makes these high-pitched noises that gives away her location.

The longer the Survivor stands in it, the more damage the Survivor takes from the goo. This ability allows the Spitter to aid other Special Infected; for instance, if a Hunter pounces a Survivor, a Spitter can spit upon that Survivor, causing even more damage. However, in spite of such a useful ability, the Spitter is very weak in terms of health, so taking out a Spitter is an easy task.

Upon death, the Spitter leaves a similar, smaller kind of puddle that has the same effect on the Survivors. She is one of the most powerful Infected if Survivors are caught standing in her spit, and are too distracted to move quickly due to other Infected or a lack of awareness at damage being dealt. On Scavenge Mode or any finale requiring gas cans, when they are dropped, the spit will ignite them if left in the goo long enough.
Computer-Controlled
The Jockey is a Special Infected that appears in Left 4 Dead 2. He is a small Infected that attacks Survivors by clinging to them from behind and literally riding the Survivor while attacking them. He can shift his weight around and cause the Survivor to stumble in his desired direction, giving this Special Infected a type of control over the Survivor. He will only let go if his victim becomes incapacitated, or if he gets knocked off/killed.

Survivors who are being ridden by the Jockey can attempt to "resist" the Jockey, causing the Jockey to slow and even pause for a second, which allows other players a chance to catch up and knock the Jockey off. Jockeys can ride Survivors into dangerous situations, such as into natural hazards, Witches, or other Infected; a Jockey can also pull a Survivor off a ledge, causing them to become incapacitated, or riding them to their death if they are not resisting. The Jockey seems to have a spinal disease, similar to kyphosis, giving him a hunched appearance. He also has a maniacal laugh (which gives away his location) and is constantly twitching, giving him a sort of hyperactive nature.
The Smoker is an ambush class that can strangle Survivors with their long tongue, similar to Half-Life's Barnacle. The help of another Survivor is required to escape from a Smoker's hold (though if quick enough it is possible, though difficult, to kill a Smoker who has already grabbed you, earning an achievement). As the name implies, Smokers emit smoke when killed to impair Survivors' vision.

A Smoker also will frequently cough, letting the Survivors know when he is in the area. The Smoker can drag players that he has captured with his tongue towards himself, though he remains stationary and cannot move. The Smoker is also momentarily paralyzed for a few seconds after having his tongue removed from his captive by another Survivor. In Left 4 Dead 2, the Smoker has six tongues, but this has no effect on gameplay.
The Tank is the biggest and strongest of all the Infected and is reasonably fast, only slowing if hit with large amounts of automatic weapons fire or when lit on fire (Versus in Left 4 Dead only and any mode aside Versus on Left 4 Dead 2). He is the only player-controllable "Boss Infected." If any Survivors at 40% or above health (including health gained from pain pills or the Adrenaline Shot) are running away from the Tank, it will not be able to catch them, as they can run slightly faster (unless the Tank in question is an AI Tank in Left 4 Dead).

The Tank has incredible strength and resistance―his punch can send Survivors flying, rendering them temporarily defenseless, and in Expert mode, instantly incapacitate them. The blow can send Survivors off high hazards to their deaths. He is also capable of throwing chunks of concrete that he rips out of the ground to momentarily stun Survivors, dealing the same amount of damage as a punch would. He can also punch large objects (e.g. a car) in the direction of Survivors with enough force to incapacitate them instantly.
The Witch generally only appears a few times per campaign, and is passive unless provoked by flashlights, gunfire, or Survivors in close proximity. She is the second "Boss Infected." Pistol fire does not provoke her easily, but it will do only a small amount of damage (in Left 4 Dead 2, causing any damage to the Witch will instantly startle her). She is very powerful, capable of incapacitating and even killing Survivors with one hit. When the Director spawns a Witch, the faint chord of the Witch music will play, allowing veterans of the game to quickly prepare for the "obstacle."

The Witch cries loudly. When nearby, Survivors will mention they hear her and warn teammates to turn off their flashlight. While the Witch can be killed, her increased health makes this difficult. It is best to avoid her if possible. Witches can be startled if a Survivor stands too close to her, damages her, or shines their flashlight on her from a close to moderate distance. She will also start to growl if a Survivor looks at her through the Hunting Rifle/Sniper Rifle's scope for a long time.

The Witch is very rarely found in small rooms and normally stays off the main route, but has been found in front of safe rooms (or even inside the safe room), doorways, and in the middle of streets. Once a Witch has killed a Survivor or cannot pathfind to her target, she will retreat from the area and despawn. However, in some strange

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