-Rise every character accuracy to 80-90% at least, then i usually go for counter or luck, it's up to you.
-Use melee weapons as often as you can (especially axe and baseball bat are really good).
-Lots of monsters are imune to tranquilize, fire, energy, cold... remember it from combat to combat.
-Save, save a lot because it's really easy to be overwhelmed by monsters, especially at mid game.
-Split non-ammo consuming weapons and tranquilizers so every char can use his own thing.

Begin the game by walking south of the boat, before you realise you'll find yourself in a battle with a Sfink (40 HP).
Walk a bit more south and you'll find half of Group One dead. When the conversation ends, you'll see a board to the left of the dead guys. Take it and continue south, now you'll fight 2 sfinks (40HP)
Take a note to your south and open the box to the left of the screen. Inside you'll find a flamethrower, a bat, an axe and some medical tape.

Then go west and up the ramp, go all the way north and use the board, Jarek will cross it and fall into a fight with 1 sfink (40HP) 1 fang (70HP) 1 cutter pill (50 HP, appears at 5th turn)
(the rest of your group will come at 7th turn).

Go again all the way down and west to meet Wasilij Dobrovsky, talk to him, and when you're done, you'll end up in a fight with a Cutter Pill (50 HP), 2 Garcias (60 HP, 1 appears at 5th turn), and 2 Sfinks (40HP).

Go a bit north, but not to far, and right so you'll be exactly in front of the boat with the singing
mutant. Climb the ladder and open the door on top of the building. The code for the safe is PLEASURE (75327873) . Inside, you'll find a shocker, 8 shotgun shells, 3 painkillers, and a few grenades.

Exit the room, climb back down the ladder, and proceed at the box northeast of your screen. you'll need to fight 2 Garcias (60 HP) and SAVE the singing mutant. In the box, you'll find a light vest, a few tranquilizing darts, and a few medical bandages.
Take all then go back, go left at the stairs and north to fight Judge (200 HP) and 4 Judge Childs (20 HP).

With that fight over go north and into the shop, there, you'll find the first MATRIX DISK. Go and open the box on the other side of the room for 1 uzi, 6 shots of uzi ammo, 24 rifle shots, and some medical tape.

Go south back to the 2 dead bodies then go to the gate, you'll fight 3 garcias (60 HP 1 appears at 4th turn) 1 sfink (40HP appears at 5th turn)
After the fight go south and enter the house, pick up the rubber gloves from the floor, then exit, go
south some more and you'll get involved in a fight with 1 Sfinks (40HP) 1 Garcia (60HP) 2 RC28 (75HP)
After the fight, grab the Oxygen tank just south of the fight, then west to a box with 6 pistol shots, some food, and a crowbar.

Go where you met Wasilij Dobrovsky. Once there, go south and you'll see a fence, use the gloves with the electrified fence and descend the stairs. Go south a few steps and you'll fight Grandma (200HP) 3 Grandma Childs (25HP).
After the fight get the "Hand" from the floor, go into the shack next to her and get a
tranquilizer gun, 2 grenades, and 8 throwing knives. Now go into the tunnel and walk up to the rocks, use the oxygen tanks with the rocks, then walk back, and use the pistol with the tanks.
Once the dust clears open the hidden box and you'll get a napalm launcher, 3 shots of napalm, some food, and a missile.

Go back to the hand identification machine east of the dead bodies to use the hand, the doors will open and you'll fight the Smokerider (300 HP) in the battle there is a chest containing 3 stun bombs.
after the fight, open the door at the north and enter, inside pick the note and open the box for some Vodka, 1 Uzi, 6 Uzi Ammo and Bandages.

Go south through the right gate, you'll run into some thieves, they leave, dropping their loot.
After the talk take everything from Wasilij, then look with the camera for a box at your
southwest and open it for: 3 Grenades, 2 Molotov Cocktail and 6 Rifle Ammo.

Go south some more and Wasilij will leave you, immediately after, you'll be pitted against 4 Hornets (50 HP) and 2 Garcias (60 HP) in a battle with some chests (East: 1 Bullet Proff Vest, 3 Adhesive Tape, 12 Rifle Ammo and south 1 Tranquilizer, 5 Darts and 3 Bandages)

You'll automatically go down to the sewers to fight against 2 Cutter Pill (50HP) 2 RC28 (75 HP)

When you finish the fighting, you'll find another body of Group One. Open the
box to your left, it has a vest, a stun bomb, and some painkillers and get into the sewers

All you need to do here is just walk along the side to the southern part of the sewers. Cross the plank then walk to the eastern part. Cross the plank, speak to Joan McFadden and she joins you.
-She has a bonus that when she heals someone or herself, she'll add 15% more healing-

Go the northern part of the sewer, oOpen box, get darts, 12
bullets, some tape, and 2 bandages. Cross plank, go to the box at the western part, open the box and get some throwing knives, 2 molotov cocktails, and some food.

Turn the valve, and cross the plank to the center island. Climb the stairs and flip the switch. Go back down and go to where the acid was, turn the valve to turn off the steam, and proceed to the ladder.
You'll be tossed into a fight with 3 Hounds (40 HP) and 1 Fang (70HP).

Climb the ladder.

Start this by going south and getting 5 painkillers, 3 cans of food, 2 grenades, and 3 molotov cocktails from the box.
Next to the box, you'll see an iron drawer, open it and retrieve another MATRIX DISK. After bagging the disk, you'll be thrust into a battle with The Fatman (250 HP) and 3 Hound (40 HP appears at your 3rd turn)

Go back to the big hand in the middle of the room and proceed northeast, you'll see a yellow card. Go get it. However you'll encounter 2 Jet-Elmers (100 HP) and 2 Cutter Pills (50 HP) on the way
get the key and go back to the big hand.
Go west now, toward the box under the stairs. You'll find yourself in a battle with 4 Sfinks (40 HP), and 3 Siners (70 HP, 2 appears at 3rd turn).

When the battle is over, open the box to your north to get some uzi ammo, healing ointment, some food, and 2 vodka bottles.
Take them all, and go directly south for another box that has 6 shotgun shells, 24 rifle slugs, a crowbar, and 18 bullets.

Exit the level by going up the stairs and out the door.

Go upstairs and all the way around and go to the exit to go to a kind of balcony and open the
chest there to get 3 Time Bomb, 6 Rifle Ammo and Adhesive Tape.
Go back downstairs, at the intersection go right in the stairs, go all the way down to a box with 3 Time Bomb, 3 Grenade, 8 Shotgun Ammo and 2 Gas Antidote.
Go north from the box to fight versus 3 Hound (40HP) 2 Sfinks (40HP) 1 Headnail (50HP) 1 Garcia (60HP) 1 Jet Elmer (100HP)

Go northeast where there will be a battle where you'll have to save another mutant, named Medusa. There will be a Cutter Pill (50 HP) trying to kill him and a Jet-Elmer (100HP) trying to kill you. The mutant thanks you, and joins you.
There's a box right southwest of you with 8 Rifle Ammo, 3 Adhesive Tape and 2 Bandage.
Then go back to the monitor and just a little Northwest there's a box, inside is 1 Tranquilizer, 5 Darts, 1 Vest and 2 Bandage

Take all and go to the monitor, right-click and select "Use Yellow Passkey" and prepare for a really though fight:
1 Hound 40HP 2 Headnail 50HP (1 appears at 3, 4th turn) 3 Garcia 60HP (1 appears at 3, 4th turn other appears at 6th turn) 1 Jet Elmer 100HP 1 Fang 70HP (Appears at 6th turn)
-You must protect the Monitor at all cost, if blown up, game over-
After the fight, go upstairs and through the now opened door to reach another part of the
Museum

Walk across the platform and down the stairs, then proceed to the box over to the east.
Before you get there, you'll be flung into a battle that has 1 RC28 (75 HP), 1 Fang (70 HP), 1 Jet-Elmer (100 HP), 1 Headnail (50 HP), 2 Siners (70 HP) and 1 Hound (40HP).
Open the box and receive 6 ultrahealers, 12 clips of uzi ammo, and 2 bottles of gasoline.
Proceed directly north and you'll come across a Polish girl, she's in shock, and a few monsters are trying to kill her.
KILL THE GIRL!
The girl mutates into a demon so you'll be facing 2 Jet-Elmers (100 HP) and the girl (75 HP).

After the fight go a little right but don't grab the cardkey yet, instead go a little north and open
a box for 5 Food, 24 Pistol Ammo, 5 Darts and 4 Adhesive Tape.
Now grab the Cardkey to once again fight, this time against 2 Lilith (75 HP) and 2 Headnail (50HP)

Proceed east and up the stairs, follow the walkway and you'll find yourself in the observatory. Go west and pull the lever. Now open the box at the south for 4 grenades, 24 rifle slugs, 4 shots of napalm, and a few medical bandages. Walk up the stairs and use the orange keycard with the scanner. This will create a bridge that allows you access to the roof.

As soon as you get to the roof, you'll have to face 9 Pain Gods (50 HP).
Proceed north by northeast and you'll find the Stinger (400 HP)
-Medusa has tranquilizing protection su use him to lure the boss-
After the fight move a little west to see Medusa go crazy. Now you have to fight him (120 HP) along 1 Lilith (75HP) and 2 Pain God (50HP)

Go north to a box for 4 Throwing Knife, 5 Food and 2 Healing Ointment.
Go south once more and you'll see a box. Inside it, you'll find 3 stun bombs, 2 molotov cocktails, and 3 painkillers. Open the door slightly to your north, and you'll hear a man say "Leave me alone or I'll blow everything up!" Use a stun Bomb against the door, a man named Slavsky will come out and join you.

Go back to the observatory bridge, and to the west you'll see the red key. Go grab it. As soon as you have done so, you'll find yourself fighting 2 Headnails (50 HP), 1 Jet-Elmer (100 HP), and 2 Pain Gods (50 HP).
-you need to finish this fight in under 6 turns or the bombs will explode-

When the combat is over, open the box to the south and get 6 rifle slugs, a shocker, and 2 tranquilizer antidotes. Now you have the red key, so go back to the first floor of the museum and use it with the monitors.
The blue lasers will disappear, and you'll have to fight your way out against the Guard (350 HP) and 2 Lucys (100 HP).

Be sure to take everything from McFadden before going to the streets.

Proceed west until you come across a battle in which you will be facing 2 Garcias (60 HP). An invisible monster will come out and bite Joan, poisoning her, you must finish the fight before she runs out of health due to the poison and you cannot remove it.
Once finished, Joan dies.

Proceed west to open the box. Inside you'll find 4 grenades, 18 rifle slugs, 18 uzi clips, and 5 medical bandages. Now follow the street south until you see the parking garage. Enter the garage and open the car trunk, you'll find a demon-attracting device (it also attracts human soldiers, why not?)
Open the box to the north for a liquid nitrogen thrower, a kevlar vest, 3 napalm shots, and 3 stun bombs. Exit the garage.

Follow the street west until you see a blue/white truck parked up against a street light. Go south into the yard and up the stairs. Open the box for 12 uzi clips, 4 grenades, 4 ultrahealers, and 18 pistol bullets. Now, pick the operative that has the crowbar and send him inside the house. Use the crowbar with the boards on the far wall to reveal an ION CANNON. Exit the room through the hole in the wall to the east.
Once outside, open the lid and get the third MATRIX DISK. Go back outside with your team. Exit into the street and you'll encounter 2 Jet-Elmers (100 HP), 2 Squeakers (110 HP), and a woman (80 HP). You must save her

-Optional battle, if you want, you can go all the way around back outside the museum-
Go north through the tunnel and you'll come across the Puppet (450HP)

Head north and out of the tunnel. You'll see a VCR repair shop to your north. Go in it. Before you can, you'll have to fight 1 Squeaker (110 HP), 2 Needles (70 HP), 1 Reverend Insect (80 HP), and 2 Garcias (60 HP).

enter the VCR shop. Get the box at the far wall. Inside, you'll find 6 attack gas grenades, 1 energy beam, 4 ultrahealers, and 12 rifle slugs. Exit the shop and go west to the abandoned tenement. Inside, you'll see a box to the east open it and you'll find: a key, 5 tranquilizing darts, another flamethrower, and the last MATRIX DISK. Leave the tenement.

Go back to the VCR shop, from there, go north and you'll meet up with General Kozov and his men. You'll end up fighting them, there'll be General Kozov (100 HP), and 7 Specnaz (60HP).

When you're done, walk on a bit, but not too far! If you go too far you'll be in a fight where you'll be facing 4 Needles (70 HP) and a Sister Of Mercy (100 HP) and you can't miss a shoot in that battle because if so, the barrels of gasoline of the truck will blow you up.
Instead, you'll see a box to the northwest (land-marked by a yellow hue lighting). Guarding it is a boss called the Cripple (400 HP).

Inside the box is a rocket launcher, 8 shotgun shells, 3 drugs, and some tape. Go back to the museum grounds after you have collected those items. Once inside the gates, go west and follow along the gates until you cone across a statue that looks like a missile. From there,
go north until you reach the gate. Use the key on the gate and enter the yard. Climb the ladder and walk toward the box. You'll have to fight 2 Reverend Insects (80 HP) and 2 Lucys (100 HP).
Inside the box, you'll find 6 rockets, 1 bulletproof vest, 12 rifle slugs, and 6 bandages.

Now, go to the hotel. Blow up the door with the rocket launcher, and fight your way inside. You'll be up against 2 Squeakers (110 HP), 3 Needles (70 HP), and 1 Reverend Insect (80 HP).
Once inside, open the elevator doors and go up. When you get out you'll have to fight 1 Pain God (50 HP) and 1 Reverend Insect (80 HP).
Inside the box you'll find 3 gas grenades, 1 lighting strike, 1 kevlar vest, and 3 crazy tabs. Go
back on the elevator and go back to the lobby. From the lobby, go down
again.

Once off the elevator, go up some stairs and open the box. You'll get some grenades and medical supplies.
Take anything worth salvaging off of Hutchens and Slavsky. Exit the basement and you'll come face to face with Messiah (170 HP).
-You must first let it attack you, so you can hit it, otherwise, you'll always miss and you must be just in front of him to damage it-

Go a little north and open the box for 1 Liquid Nitrogen Launcher, 6 Uzi Ammo, 8 Shotgun Ammo and 6 Adhesive Tape.
Then go west, open the door and enter, go all the way down and switch on the Main Computer,
then exit, go northeast to a train and a strange spark to fight 2 Incubus (150 HP) and 2 Reverend Insect (80HP)
-Game can crash in this fight so try to kill 2 reverends first and then the 2 incubus in the same turn-

You will be teleported back to the beggining of the lab, go north of it and then east for abox with 3 rockets and bandages. By north you'll be stopped by a NATO Patrol of 5 soldiers (100 HP).
Enter the building and pull on the lever to retrace the train, go all the way through the track to fight 2 Harvester (100HP) 2 Sister of Mercy (100HP).

Then go north through the bridge to open a box for 3 Rockets, 3 Napalms, 6 Rifle Ammo and 6 Bandages. A little west there is the teleport controller, switch it off.
Go all the way soth to reach another box with 1 Energy Blaster, 12 Rifle Ammo, 1 Kevlar Vest and 4 Gas Antidotes.
Down the stairs all way to the west there's a box with 4 Time Bomb, 4 Shotgun Ammo, 5 Darts and 4 Ultrahealers.

Now go to the central machine, you must fight the invisible enemy that killed McFadden, and you
can not see them, worse yet, when they attack you, they poison you.
- you must remember where they finished their move, or when you try to move the cell where they stand doesn't appear green-
5 enemies (40-50 HP?) and they have protection against everything, you need to use normal shoots or melee attacks.

Go north to the Voltage Generator and switch it on, now go all the way back to where you fought the Incubus, turn on the computers you'll see to the east, and go west to put the MATRIX DISKS into the drives. You'll meet up with the not so dead Wasilij Dobrovsky, he will reveal all the Gorky 17 thing here.
NATO will interfere and you'll be forced to fight them, 3 soldiers and General Lamar (100 HP).

When that's over the dying Lamar will try to convince you that Dobrovsky is with Kozov and you will fight the final boss, Mutated Dobrovsky (500HP)