The Infinibomb is the best and most overpowered item in the game. It's extremely cheap to make, and gives you an infinite amount of bombs. Here's why it's good.
How to get it: All it cost is a few slime and a bunch of sand. You get the recipe by levelling up, which happens quite fast, and once unlocked you can access it very early in your run.
1. Bombs destroy harvestable objects, like rocks and trees, in one shot. They have a big range, so they can harvest literally dozens of your trees all at once. This can save you HOURS of harvesting junk. Just grow all your trees close together (there is NO penalty to planting trees directly beside each other), and when fully grown, one bomb can blow your whole forest to bits, then you just have to harvest them.
2. They kill mobs very easily. Basically every enemy in the game, except for bosses, are killed by one bomb. The only real difficulty is not killing yourself. I recommend always having a cloning station, once you can make one. The other tip would be how to throw them, if you jump and immediately throw the bomb, it will have a really nice arc to it, and if you give it momentum, it can travel quite far. You can actually throw the bombs farther than aggro range, meaning, a mob won't even know you exist yet, and you can throw a bomb right on top of it. This process is quite easy to get used to, and quite accurate and predictable. I became an expert at this quite fast, and could basically snipe enemies with bombs, which was quite fun, and effective.
3. Bosses become incredibly easy. Honestly, it's just so easy...

The shovel is the least appreciated item in most games. If you're playing Wrongworld, it's probably the case that you enjoyed Minecraft. In Minecraft, you basically never make a shovel, because it's stupid. Not the case in Wrongworld. Digging is actually an extremely effective tool for a few main reasons.
1. Digging holes is an extremely effective way to get materials that are otherwise quite annoying to get. Sand is very plentiful if you dig in the desert, and ice is everywhere if you dig in the snow. Obvious, I know, but at first I was playing and found next to no sand or ice, so I wasn't able to make some things, and basically just did without. After realizing this trick, I have more sand and ice than I know what to do with.
2. Caves pop up quite often if you dig. Personally, I found digging in some areas gave me more caves than others (desert gave very few, grass gave quite a lot). Caves are an absolutely essential part of the game. If you use the bomb (and vacuum) trick, you can just throw a bunch of bombs in, killing and harvesting everything in the cave, and grab it all up, very quickly. Caves have tons of trees and rocks, and even ore rocks, so you get a lot of materials. Additionally, caves always have "something" unique in them, be it a rock/copper/iron/gold seed, a tool/weapon, or something else that's usually valuable. Honestly, one of the fastest ways to advance in this game is just to raid/loot cave after cave after cave, and the shovel is what gets you there.
3. Seeds are actually kind of rare, and if you want to survive, you need food. Digging (I found in grass) gives quite a lot of seeds, so it's actually a nearly essential step if you want to stay well fed.

The downside is, the vacuum "weapon" takes quite a while to be able to make, because it requires the advanced machinery. However, it can suck all nearby items in, in just a few seconds. If you follow my advice on bombing your trees and rocks, the vacuum can make extremely short work of picking all the materials up, which, again, saves you a LOT of time. Also, if following the shovel trick, you can just dig a ton, then use the vacuum, again, saving tons of time. With these tricks all used together, you can get massive amounts of resources, extremely quickly, with very little threat to your well-being.