Melee Attacks from stealth are always critical.

Works with all types of stealth, including Chaos Waste Potion of Stealth effect.

Parrying an Attack and quickly Dodging grants Kerillian Stealth for a short period.

After blocking an attack with Timed Block, dodge within 1.5 sec grants you stealth for 1.5 sec.
You can walk through enemies during stealth.
The extended stealth will instantly break after one attack.

Charged Critical Backstabs instantly slay man-sized enemies.

Javelin charged melee attack also counted.
Man-sized enemies include all enemies without health bar except Chaos Warrior and Wargor.

Landing an attack on enemy breaks the stealth.
Only melee attacks benefit from the bonus damage. For dual-wield melee attacks, both attacks receive a damage bonus.
The bonus damage can be boosted/stack with all types of buff like Strength Potion/lvl15 talents/Headshot, except her passive Assassin's Blade.
The bonus damage amount is dependent on which melee attack it is applied to. The stronger the original attack is, the higher bonus damage will be applied.

Providing 100% additional damage when backstabing.
Damage increase is only related with attack base damage. It is not affected by Headshot/Critical Strike/Strength Potion/Infiltrate

1

Dual Daggers - Heavy Attacks
Sword & Dagger - Heavy Attack 2

2

Elven Axe - Heavy Attacks
Sword - Heavy Attacks

3

Elven Spear - Heavy Attack 2

4

Javelin - Heavy Attack

5

Dual Swords - Heavy Attacks

6

Great Sword - Heavy Attack 1

7

Glaive - Heavy Attack 2

Should be used most of the time.

Should be used if you melee weapon is extremely hard to land headshot.

Should be avoided most of time as a melee elite killer.

Consistent boost for Infiltrate
Same as 50% Crit Power.
Since Infiltrate grants first attack 100% Critical Chance, it is a very good consistent damage boost for Boss bursting purpose. And thanks to Elf weapons' high average base crit damage, it also provides a decent DPS increase in other situations.

Consistent damage boost for few builds with specific weapon choices
The attack that applies the Poison/Bleed effect also benefits from Exploit Weakness.
The poison/bleed effect on the enemies does not need to be applied by Shade. But only Shade benefits from the damage boost.
The 20% damage boost can increase Infiltrate damage similar amount compares to Cruelty. However, due to the nature of Infiltrate, it requires the player to apply Poison/Bleed effect before using Infiltrate, as all strong melee attacks that receive the most amount of Infiltrate damage do not apply bleed/poison by themselves.
Overall only builds that utilize Dual Daggers and/or Hagbane Shortbow can benefit from this talent consistently.

Extremly high damage boost that requires good executions
The damage bonus is applied to both melee attacks and range attacks.
Both melee attacks and range attacks can refresh this talent's duration.
Scoring multiple headshots with one attack grants multiple stacks. For dual-wielded attacks, each individual attack can score stacks.
Since Elf weapons have high average base headshot damage, with a decent headshot rate this talent can provide the overall highest amount of DPS in all situations on the level 10 row.
However, it is can be hard to set up 10 stacks and then land a headshot while using Infiltrate, so even though its Boss burst potential is the highest, it is also the hardest to pull off.

Increase your melee single target DPS.
However, with a high base Critical Strike chance & decent headshot rate,
it is inferior to Assassin most of the time.
Plus Assassin provides a much higher horde damage boost and Infiltrate damage boost.
Should be avoided most of the time.

Increase your melee single target DPS.
With a high base Critical Strike chance & decent headshot rate,
it is better than Smiter most of the time.
Plus Assassin provides a much higher horde damage boost as the critical strike damage boost work on all enemies you cleaved instead of the first one.
It also gives a higher boost to Infiltrate, as the first strike after Infiltrate is always a Critical Strike.
Should be picked mosf of the time.

Increase both your melee and range damage. Does not benefit a melee focus career as much as other talents.
Should be avoided.

Low use case damage boost
The Backstab Damage increase does not work with the charged backstab that triggers it.
Can only get 1 stack per attack, even with dual-wield attacks.
Due to the nature of enemy agro, it is hard to pull off backstab except during pacing or horde fighting. Even if trying to use backstab from stealth or with Shimmer Strike, Shade can already instant kill man-sized enemy with her perk. Plus this talent doesn't provide any meaningful backstab kill breakpoints, this talent is only useful for long last single target fights, like Boss and Lord.

High use case utility
After killing an enemy with melee backstab, grants 100% of cooldown regen for 3 seconds. Duration can be refreshed.
Regenerate an extra 3 sec of cooldown during that 3 seconds window.
A good cooldown talent to increase both your damage output and survivability, especially when paring with Shimmer Strike.

Good ammo sustain for special sniping purpose
Does not work with Moonfire Bow.
Can farm ammo fairly consistently during pacing/Boss fight, or when paring it with Shimmer Strike.
Dual wield attacks like Dual Daggers heavy attacks cannot refund 2 ammo.
Enough to farm ammo sustain for special sniping weapons like Longbow or reduce the recall pressure on Javelin. But it doesn't give enough range resources to spam some horde clear weapons like Volley Crossbow/Hagbane Shortbow.

High consistency damage reduction during engage
Due to Shade high base crit chance and fast Elf weaponry, this talent has basically 100% coverage during fights.
Damage reduction gives you more leverage when fighting horde and tanking special damage like gas/blight. However, even with this talent activated Shade is still very squishy, still cannot tank an Elite overhead with full health on Cataclysm.
High floor, low ceiling. Good for complicated fighting senerio.

High consistency movbility during engage
Due to Shade high base crit chance and fast Elf weaponry, this talent has basically 100% coverage during fights.
Movement speed gives you an easier time at evading enemy attacks, as you can move out of their hitbox or move to a more favourable fighting position easier. It also allows you to backstab elites easier during Shimmer Strike since you need to catch up elites while they are running away due to the lack of agro.
However, if the fight does not allow you to move around easily or you fail to evade attacks, this talent's value drops severely.
Low floor, high ceiling. Good for fighting at the open area and experienced players to evade & position better.

All time consistent movbility
Like Spring-Heeled Assassin, it's a talent made for mobility. However, it has a lower movement speed bonus but 100% uptime, making it worse at evading enemy attacks during massive fights or back during Shimmer Strike, but better at finding backstab/items during pacing or speed run. This talent can also bring the side effect of being out of position/far away from your team too easily when there are no horde fights.

Mass man-sized elites/mass special focus
Stealth can be extended by melee/range/bomb killing special or elite enemies.
As long as the attack from stealth killed a special or elite, even if it hits other units simultaneously and fails to kill those units, you will still be in stealth and stealth duration is extended.
The extended stealth will instantly break if the next attack that lands on an enemy fails to extend the stealth duration.
With the perk Dagger in the Dark and Murderous Prowess, this talent allows Shade to execute as many man-sized elites or specials as possible in its duration. Combine with talent Focused Slaying, you can do it very often on high difficulties. You can also use this talent to snipe multiple specials from safety but it requires you to oneshot kill them.

Horde focus
As a power boost, it increases your damage/stagger/cleave.
The power boost also increases the damage of the stealth attack that triggers it.
Provides good horde clear DPS boost. The movement speed and phase walk also allow you to evade enemy attacks, move to favourable horde fighting position or pick up elites inside horde without dropping agro easier.

Boss and Chaos Warrior focus
Allows two attacks being buffed by Infiltrate damage bonus. Can deal huge Boss/Lord damage, or delete at least two Chaos Warriors with ease.