Plague Inc: Evolved

Plague Inc: Evolved

770 ratings
Virus - Mega Brutal Guide (Guaranteed Win & Perfect Score)
By Tatsur0
The Virus campaign is a difficult one as it's quite volatile but with this guide you'll be able to decimate life on planet earth on any difficulty though this guide focuses on Mega Brutal and with a perfect score no matter how often you try it.

(NOTE: This guide states a Guaranteed Win & Perfect Score because it guarantees it so long as special events or closed ports like Greenland that while prepared for still create random chance and there is no guarantee that your first go of it will lead to either a win or a win with a perfect score but if tried a 2nd or 3rd time will lead to what is promised! It is impossible with all but Necroa-Virus & Fungus to guarantee a win each and every time due to random chance which we have influence but no direct control over.)
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Virus - Introduction


Virus - Mega Brutal



This guide focuses on the volatile "Virus" campaign. It's aggressive nature is something we let loose rather than try and control. With the right Genes, Transmission, and Abilities (you left out Symptoms? Well yes but only because the nature of this virus mutates most of them and of course there are some vital Symptoms and we will go over them but lucky for us it's not like usual something we worry over much till later and only to expedite righteous cleansing!) we can help nature do it's thing mostly on it's own.

I'll show you how to win 100% of the time on any difficulty with our focus on Mega Brutal and with a perfect score for those completionists out there!

Shall we begin?
Virus - Genetic Code
Here are some common but important genes you'll want to use to end humanity with a perfect score 100% of the time.



  • ATP Boost
    • Instead of leashing our Virus we use the extra DNA from this gene to set it free to be even more destructive and out of control. Freedom! ...wait is there a lesson here? Nah!
  • Genetic Mimic
    • A gene that makes it harder to cure disease.
  • Aquacyte
    • We have to be very wary of Greenland in this campaign so we need as much help infecting our Islands so this is a must have gene.
  • Urbophile
    • Sweden likes to close down it's borders and ports before our Virus can sneak in so with this and what we spend DNA on there won't be any neutral ground this time.
  • Sympto-Stasis
    • While our Virus loves to mutate and we of course encourage this there are still important Symptoms we need to speed up the destruction which is explained further on in the guide.
Virus - Choose Starting Country


Like my other guides I've pointed out how Saudi Arabia is a great starting point allowing us invade Europe, Asia, and Africa with little help needed and our focus on the rest of the world that much easier with the extra DNA.

Virus - Abilities :: Phase One
Again, the last thing we want to do is hold the nature of this virus back but instead give it the push it needs! Let's see just how hard we can push it.



  • Viral Instability 1
  • Viral Instability 2
  • Viral Instability 3
    • This ability only takes an unstable and dangerous virus and increases it's erratic behavior with mutations sprouting out left and right allowing us to focus elsewhere for the time being... Like Greenland and their love of shutting out immigrant...viruses.
Virus - Transmission :: Phase One
The place so many mistake for Iceland... Greenland with all that beautiful snow (don't worry I'll try to stop obsessing) will be tamed if you follow this guide exactly while in most cases randomly determines a win/lose as soon as ports are closed so our goal will be to sneak in asap!



  • Water 1
  • Air 1
  • Water 2
    • Not only is Water 1 & 2 a great way to spread the virus but a must for shipping overseas to open ports (before they can close)
Virus - Abilities :: Phase Two
Swapping back and forth may seem confusing at first but a port we wish to breach requires we sort out the right evolved traits and the sooner the better!



  • Cold Resistance 1
  • Cold Resistance 2
    • We've prepped Water 2 but Greenland is cold so we need to make sure our virus is ready for the weather! This is where we seal the deal and can stop worrying about the largest Island on the planet barring our way!
  • Drug Resistance 1
  • Drug Resistance 2
    • Powerful nations think they're safe but that is just an illusion once their antibiotics fail them.
  • Heat Resistance 1
    • We started in the Sun and yet Africa laughs at us and talks to South America and Australia behind our backs... as we sneak in Heat Resistance. We'll see who's laughing in the end (Me... I'll be laughing).
Virus - Transmission :: Phase Two
Alright, with the largest Island now open to the death we're dealing we still have others like Sweden who are quick to close their borders and ports thinking themselves safe. Fly birdy, Fly!



  • Air 2
  • Extreme Bio-Aerosol
    • We can now help spread to other Countries by land, sea, and air having already targeted the safer zones but make no mistake, we still have a planet to global ban!
  • Rodent 1
    • Should help spread through Urban areas speeding up the end!
  • Bird 1
    • Thinking of closing your borders? Sorry but these guys don't see the lines on our maps. Welcome to the party!
Virus - Symptoms


Oh it looks like some scientists figured out what we're up to.



We can't have that... Now our Virus has mutated numerous symptoms but we have spare DNA to further infect but more importantly disrupt research and kill off all those who would try to stop us, their friends, families, and everyone else for that matter!



Now humanity is ours! But... they're taking their sweet time. Use up the rest of your DNA to kill off the stragglers and finish the job.



Focus on the following symptoms if they haven't already mutated:

  • Necrosis
  • Dysentery
  • Total Organ Failure
  • Any other symptoms that boosts fatality rates that you can afford
Virus - Conclusion


If you followed the steps accurately congratulations are in order! Humanity has no future, you've seen to this and victory is yours!



Your scoreboard should show both a Mega Brutal victory but also a perfect score 5 of 5!



I will be continuing to work on these Guaranteed Mega Brutal Perfect Score guides in the hopes of finding the right setup for each and everyone. If you have any questions be sure to ask and either I or Barry "BMcC" McCockinner who I run these past for further testing and collaborate with will answer you asap!

For those that don't follow my Weekly Contagion & Other Indies Stream & Giveaway I did one for Plague Inc: Evolved if you'd like to check it out!


Sorry but it does not let us embed a time-stamp. Plague Inc: Evolved portion starts at 5mins 10seconds.

Check out my other guides - https://steamhost.cn/steamcommunity_com/app/246620/discussions/0/43099721963116155/

Wishing you an enjoyable mass extinction event (Virtual of course! Shouldn't have re-watched 12 Monkey's last night)!
170 Comments
Vene 9 Jul @ 11:12am 
Love your guides. Always a huge help. 5/5 first try :)
BenT 4 Jun @ 11:24am 
Tried it 5 times never worked. The virus kills the infected faster than it infects new people. They don't have to cure it, it destroys itself every time. Thanks anyway maybe a patch changed it, not sure but it doesn't work now.
Solaire 24 Mar @ 5:43pm 
This guide really helped me, once I did everything on this guide the world fell to my virus in a couple minutes, thank you.
24 Jan @ 5:35pm 
i repeated 2020 in plague inc on mega brutal with my covid-19 virus and actually won this dude's a W
AntiHackerAction 17 Jun, 2024 @ 9:52pm 
Won on the second try. Not exactly a five score, but a four score will do!
AntiHackerAction 17 Jun, 2024 @ 9:45pm 
Damn good guide. I didn't have urbophile, but aquaphile did the job more or less. First run got screwed by greenland, but i'll get lucky next time.
Lia 2 Apr, 2024 @ 1:29am 
Thanks! 4/5 but I didn't have the exact genetic code as in this walkthrough.
antiquail 11 Oct, 2023 @ 1:53pm 
432 days 37% cure 5/5
Bob 7 Oct, 2023 @ 3:23am 
i hate my luck 4 attempts Caribbean or Greenland always shuts down before i can get there
Triksu 12 Sep, 2023 @ 8:51am 
466 days 90% cure progress