In the kitchen cupboard of Apartment 007, near the fan and the family picture, there's a Data Storage Unit that you have to pick up and scan. This can be analyzed in the Tattoo Shop Basement.

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Analyze 100 objects.

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Interrogate 20 tenants.
Knock on every door. If you're still missing some by the time you enter the Tattoo Shop, there are some tenants in the Basement Storage as well.

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Enter Apartment 104. Complete Amir Nowak's neural investigation.

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Overdose on synchronization pills.
Use 2-3 pills in a row.

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Pick up and scan the jar containing Controlled Substance 31A in Apartment 104. Visit Apartments 112 and 209.

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• Talk to Paulina from Apartment 113.
  
• Enter Apartment 114.
  
• Access computer after Pieta Sagan's neural investigation. Select CEPHALUS_7.34 and make a choice.

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Discover and access all 4 shrines:

1. In the hallway, next to Apartment 018.
   
2. Between Apartment 108 and Apartment 107, turn left, and walk to the end of the hall.
   
3. Down the hallway, past Apartment 110, go through a hole in the wall on the left, and then turn left.
   
4. Past Apartment 211.

You can now enter Apartment 207. Code: 3092. Investigate the computer.
Case continues in the Basement Storage, inside Unit 037. Code: 8394.

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• Converse with Apartment 206.
  
• Investigate Apartment 205. Scan the room and press the switch. The door to a safe located next to the PC will open. Inspect the contents.
  
• Case continues in the Basement Storage, inside Unit 028. Code: 7441.

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Finish the game without dying.

If you're caught during the sequences where it's possible to die, immediately return to the main menu and then press continue. It will load to the last checkpoint.

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• At some random point, you'll be updated with a case prompting you to investigate Apartment 108. Access computer. Password: 5232.
  
• Case continues in the Basement Storage, inside Unit 018. Code: 2689.
  
• Find the Data Storage Unit inside one of the lockers and plug it into the computer.
  
• Access PC, select C: drive. Enter 12345 as the password. Select System directory, choose PORTKEY.EXE and enter 1944 as the Port Key, and 0123 as the password. Return to root via ... and then select V: drive and choose OPENDOOR.BAT file. Exit PC.

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In the attic, cross the pigeon invasion under the wooden bars and you'll see the lights flickering just before the wooden planks. Go left, up the stairs and walk towards the glowing pigeon.

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• Inside the Tattoo Shop. Use code 3615 on the chair. Enter the room and grab the key off the table, directly ahead as you enter.
  
• After you return from the Basement Storage, enter Apartment 208. Password to hanged man's neck is ANNA.
  
• After neural investigation, read the mail on computer. Password is: 160464. Inform the daughter about the father's death.

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Complete Adam Lazarski's neural investigation.

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You need to score 3000 points. There are 3 games. The score is combined with each game. The last one offers no points.

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Embrace Adam.

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Reject Adam.

Find 10 nanophage patient cards.

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Find all nanophage patient cards in a single playthrough.
Some cards are missable. I'll mark those with '#'.

1. The hallway between Apartment 005 and Apartment 008, in the bathroom, on an upturned blue bucket.
   
   
2. The hallway next to Apartment 016, on top of a washing machine, on the right of the Strange Shrine.
   
   
3. Inside the Manager's Office, on the desk behind the first monitor, accessed after closing the door.
   
   
4. In the courtyard, near the tattoo shop, in the small annex next to it, inside the 2nd garbage bin.
   
   
5. On the left of entering the courtyard from the main building, use the computer and then access the vent between the first row of equipment.
   
   
6. In the main building, facing the twin doors leading to the courtyard, go through the metal door on the left to enter the stairway. Climb to the 3rd floor. It's on the chair under the floor map.
   
   
7. Next to Apartment 110, inside the stickered cabinet.
   
   
8. Between Apartment 108 and Apartment 107, turn left, reach the end of the hall and it's on top of the refrigerator.
   
   
9. Exit onto the balcony through the door next to Apartment 105. It's on the chair at the end of the walkway.
   
   
10. The stairway of the 1st floor, next to the door leading to Apartments 101-104. It's on the computer parts, on the left.
    
    
11. On the left of the toilet, through the door in front of Apartment 101.
    
    
12. On the right of Apartment 205, on top of electronics.
    
    
13. Inside Apartment 205, on the table next to the laptop.
    
    
14. Laundry room, on the left before reaching Apartment 207. It's on the right, in an open locker.
    
    
15. On the refrigerator door, inside Apartment 207. Code: 3092.
    
    
16. Past Apartment 211, on the floor to the right of the Strange Shrine.
    
    
17. In the cupboard, immediately on the right after entering Apartment 114, above the picture frame. Use night vision or turn on the disco ball.
    
    
18. # During Pieta Sagan's neural investigation. After reaching the shift where a little girl sings "rain, rain, go away", reach the corridor that is accessed on the left, exit, and turn around. It's attached to the grid.
    
    
19. Enter door for Apartments 201-210, turn right. Next to the door at the end of the hallway, on a shelf.
    
    
20. Through the door at the end of the hallway. In the kitchen, inside the freezer.
    
    
21. Left of the wooden door across Apartment 208.
    
    
22. On the 3rd floor, go through the door leading to the outdoor walkway. Walk to the end and enter the bathroom. It's on top of the cabinet.
    
    
23. Inside the cabinet on the wall, in Apartment 302, past the bathroom.
    
    
24. # During Amir Nowak's neural investigation. After the plaided tablecloth shift, past the score-marked hallway, enter the kitchen, look right and find it inside a cupboard.
    
    
25. # Past Apartment 209, turn right at the arrow screen. On the door at the end of the hall.
    
    
26. # Reach the shift where the cells are on the left and a side rail on the right, walk ahead to shift again ("Let me out!"), and then immediately turn around. It's on the wall, above the barrier.
    
    
27. # When you reach an open area with shower stalls lit by blue lights, approach the shower on the right and enter it. After the small shift, it will spawn on the floor.
    
    
28. Inside the drawer next to the blood bath.
    
    
29. On the generator, inside the bedroom of Apartment 108.
    
    
30. # During Helena Nowak's neural investigation. Cross to the other side of the cubicles, past the bathroom. Spot an overhead sign that rotates around and it's directly under it, inside an empty cubicle.
    
    
31. # Sequence with the music. Follow the snake, then turn right towards the red ceiling. Walk to the end and then turn left. It's on a chair.
    
    
32. # In the shift with the room that has a computer on the left displaying the text "Patient Card ready to print. Automatic Printing set to 3:20 AM". Set the time of the clock in the kitchen and return to the computer.
    
    
33. # After Helena says "I can't do this anymore", the scene will shift. Immediately turn left, go down the passageway. It's on the table at the end.
    
    
34. # Follow the cables. At the end of them, go up the stairs on the left and interact with the door.
    
    
35. # Past the red camera, continue ahead until you arrive next to a glitchy green wall, then turn right. It's in a cubicle, on the desk.
    
    
36. Use code 3615 on the chair and enter the room. It's on the right, on a shelf.
    
    
37. Go down the stairs to the basement. It's on the shelf, on the left as you enter the room.
    
    
38. On a shelf to the right, inside Unit 006.
    
    
39. Inside the refrigerator, past Unit 015.
    
    
40. Inside the last locker on the left, at the back of the room of Unit 018. Code: 2689.
    
    
41. Past Unit 016, enter a hole in the wall, reach the end of the passage, and then walk towards a short flight of stairs. It's on the ground in front of the grate.
    
    
42. Inside the freezer in Unit 028. Code: 7441.
    
    
43. On the left, in front of a metal grate, at the end of the tunnel inside Unit 037. Code: 8394.
    
    
44. # During Theodore Witkiewicz's neural interogation. Past Apartment 005, on top of an electronic.
    
    
45. # After the spotlight circle scene, go through the door and down the stairs to the bottom, and then turn left to find it on the door frame.
    
    
46. # After ending the conversation with the woman. Turn around and enter the door at the end. It's on the cabinet above the toilet.
    
    
47. On top of the radiator, inside Apartment 208.
    
    
48. # During Stanley Tkaczyk's neural investigation. Move the hospital bed blocking your path. It's on top of a table next to the left wall.

• 49. # Enter Apartment 210. Walk ahead until a shift occurs, then turn around and go left. It's on top of a cabinet, near a vacuum.
  
  
• 50. # Inside a drawer, in the kitchen.
  
  
• 51. # In the tattoo shop basement, on the floor of a raised platform, next to a Nanophage Quarantine barrier.
  
  
• 52. # On the chair, after opening the door at the end of the outdoor walkway.
  
  
• 53. After the hologram forest, on a shelf, as you approach the door with a large bloodstain on the floor.
  
  
• From this point on, everything is missable.
• 54. Past the pigeon invasion and before opening the trap door, go left and crouch under. It's on the floor.
  
  
• 55. During Victor Maderski's neural investigation. Enter the courtyard with the TV heads. Walk along the right wall until you reach the entrance to an annex, on the right. The card is inside, on the ground, in front of a pale light.
  
  
• 56. Follow the deer. After the TV asks "what's wrong with his legs?", continue to the right and open the second door on the left. It's on the shelf directly above.
  
  
• 57. After the shift showing a desk space, don't follow the deer. Go inside the kitchen and look inside the fridge.
  
  
• 58. On the seat of the third pew on the right, before reaching the church.
  
  
• 59. Reach the lobby where there's a giant Janus. It's on the window sill.
  
  
• 60. Open the silent twin metal doors, drop down in the hole on the ground, then turn around. It's on the ground, under the metal bars.
  
  
• 61. The middle locker, in the same room where the spare fuse is picked from.
  
  
• 62. Go through the door activated by the switch, turn left and go past Unit 042. It's on top of a stove.
  
  
• 63. Drop down, proceed forward to the end of the tunnel, then turn left. It's on the ground, in front of the bars.
  
  
• 64. Enter the killer's hideout. On the brick wall, above the voice recorder.
  
  
• 65. During Adam Lazarski's neural investigation. Enter the Chiron building and look down to the left of the console.
  
  
• 66. Activate the switches, go through the door, follow the passageway and after crouching under some pipes, turn left. It's on the ground, in front of steaming pipes.
  
  
• 67. Exit the tunnel, then turn left. It's on the ground, between the pipe and the wall.
  
  
• 68. As you step out and see the Sanctuary sign, turn left and walk towards a door with a Quarantine sign on it. Look on the ground, left of the door.
  
  
• 69. Before entering Sanctuary, turn right. It's on top of the organ.
  
  
• 70. On the railing of the balcony overlooking the capsule area.
  
  
• 71. On the table, left of the tube TV.
  
  
• 72. Go under the barrier. Walk ahead and spot it on a ledge, on the left.
  
  
• 73. Enter a well lit, white room and look right. It's on the small table.
  
  
• 74. The vent is in the well-lit section of avoiding the monster. On the left of the area, where the screens on the wall displays a pair of lips.
  
  
• 75. Before using the terminal, look on the right of the desk.
  
  
• 76. Past the multiple cables.

Find all RC Cars.
The cars must be picked up in order. They do not show up otherwise.

1. In the hallway, in front of Apartment 017.
   
   
2. Through the doors leading to Apartments 201-210. Turn right and enter the door at the end of the hallway. It's on the floor, in-between the first two table sets.
   

   Originally posted by author:

   Note: The 2nd car is bugged somehow. If it doesn't show up the first time you go to pick it up, return after Amir Nowak's neural investigation.

   
   
3. After Amir Nowak's neural investigation. In the courtyard, next to the tattoo shop, in the annex with the garbage bins.
   
   
4. During Helena Nowak's neural investigation. Drag the laughing-crying TV after you for this section. After opening the second door, move straight up the hallway through an open doorway, open the door at the end and pick up the car.

If you want to get only the RC Cars:

• Start a new game
  
• Scan the 1st car.
  
• Complete Amir Nowak's neural investigation.
  
• Scan the 2nd and 3rd car.
  
• Start Helena Nowak's neural investigation and pick up the 4th car.

Find all roses.
The roses must be picked up in order. Otherwise, they won't spawn.

1. In the main building, facing the twin doors leading to the courtyard, go through the metal door on the left to enter the stairway. Ahead, there's a door leading to the basement. Enter and cross to the other side. It's on the steam pipes on the right of the stairs.
   
   
2. Attached to the safety grid on the right, past the graffiti door next to Apartment 210.
   
   
3. In the attic. Cross the pigeon invasion under the wooden bars and you'll see the lights flickering just before the wooden planks. Go left, up the stairs and walk towards the glowing pigeon. Turn left and open the door to the last cage.
   
   
4. During Victor Maderski's neural investigation. In the forest section, after you pass the tattoo shop by going right. Walk to the left into the forest and you'll come upon a grave. The rose is on top of it.

If you want to get only the roses:

• Start a new game.
  
• Pick up the 1st and 2nd rose.
  
• Talk to the man in Apartment 102.
  
• Complete Amir Nowak's neural investigation.
  
• Enter the Tattoo Shop.
  
• Use code 3615 on the chair.
  
• Enter the Tattoo Shop Basement, but do not turn on the power.
  
• Check the table in the middle of the room for a bag of eyes.
  
• Return to Apartment 102 and talk to the man.
  
• Enter Apartment 210.
  
• After deactivating the hologram forest, go up to the attic and pick up the 3rd rose.
  
• Start Victor Maderski's neural investigation and find the 4th rose.

Find and listen to all patient records.
The radios must be picked in order. Otherwise, they won't spawn.

1. In the main building, facing the twin doors leading to the courtyard, go through the metal door on the left to enter the stairway. Climb to the 3rd floor and turn around to find the radio sitting atop a tilted monitor, among some wires.
   
   
2. Down the hallway, past Apartment 110, go through a hole in the wall on the left, and then turn right. Flush the flooded toilet and it will reveal the radio.
   
   
3. In the Basement Storage. On a pile of equipment, inside Unit 020.
   
   
4. Inside the Sanctuary. After interacting with the woman, proceed forward until you reach some barriers. Go past them and there will be an open area with a table. The radio is sitting on top of it.

If you want to get only the records:

• Start a new game.
  
• Scan the 1st and 2nd records.
  
• Complete Amir Nowak's neural investigation.
  
• Enter the Tattoo Shop. Ignore Helena and introduce the code 3615 on the chair.
  
• Enter the Basement Storage and scan the 3rd record.
  
• Exit Basement Storage.
  
• Talk to Janus. He's in the courtyard.
  
• Proceed with the main story until you reach Sanctuary.

Complete all With Fire And Sword: Spiders arcade games.

1. Next to Apartment 016. After activating the Strange Shrine, interact with the Holocom Panel.
   
   
2. Down the hallway, past Apartment 110, go through a hole in the wall on the left, and then turn left. Access the Strange Shrine.
   
   
3. PC inside Manager's Office.
   
   
4. Between Apartment 108 and Apartment 107, turn left, reach the end of the hall and access the Strange Shrine.
   
   
5. PC inside Apartment 05.
   
   
6. PC inside Apartment 207.
   
   
7. Past Apartment 211. Access the Strange Shrine.
   
   
8. PC inside Apartment 114, next to Pieta.
   
   
9. PC inside Apartment 303. Code is: 6359.
   
   
10. PC in the kitchen, inside Apartment 104.
    
    
11. PC inside Apartment 108. Code is 5232.
    
    
12. PC inside the Tattoo Shop, on the desk behind the counter.
    
    
13. PC inside Apartment 210.
    
    
14. PC inside the Killer's Hideout.

• Tattoo Shop - 3615
  
• Apartment 207 - 3092
  
• Apartment 303 - 6359
  
• Apartment 108 - 5232
  
• Unit 018 - 2689
  
• Unit 028 - 7441
  
• Unit 037 - 8394
  
• Collar password in Apartment 208 - ANNA
  
• Mail password in Apartment 208 - 160464
  
• Basement Storage Exit - 4004

• If for some reason, you didn't pick up the #22 card of this guide before entering Amir Nowak's neural investigation, you won't be able to pick it up until after returning from the Basement Storage. That's because Janus is using the bathroom.
  
  
• On the left of Apartment 203, there is a cabinet that you can open. A man in a hazmat suit will pop out.
  
  
• After Amir Nowak's neural investigation. if you go to the 1st floor, you'll constantly hear some growling sounds as if there's a monster nearby. If you try to follow the source, you'll be led to Apartment 110. Try opening it and you'll be greeted by the monster briefly, then the door will shut.
  
  
• Talk to the man inside Apartment 102. Then, when you reach the Tattoo Shop Basement, check the table in the middle of the room for a bag of eyes. Return to Apartment 102 and talk to the man again. You'll be able to enter Apartment 210 now.