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Red 1 or blue 1 is always easy cuz you can 1+ x 3 shots for full heal give or take
For high dose it would usually be 6 for 2+ x 2 shots.
Of course, you can always check the humor wheel for lower dose alternatives combine with the high dose for yellow/black.
Allergies nullify even perfect dosages, and give at least -2 to health, couldn't test for more.
Does a perfect does counteract this, or do the allergies nullify the perfect does and give a -2?