Hello, yes. Allergies will give -2 always so far. So I usually opt for the opposite spectrum for that specific drug = low red/blue or high yellow/black.

Red 1 or blue 1 is always easy cuz you can 1+ x 3 shots for full heal give or take

For high dose it would usually be 6 for 2+ x 2 shots.

Of course, you can always check the humor wheel for lower dose alternatives combine with the high dose for yellow/black.

Well, I just tested it (Also can't see my previous comment?)
Allergies nullify even perfect dosages, and give at least -2 to health, couldn't test for more.

I have a question about allergies, I read on a forum soemone saying allergies always gave -2 to health.
Does a perfect does counteract this, or do the allergies nullify the perfect does and give a -2?