The gateway nexus is the ideal place to build your base due to the gateways giving you faster access to the various areas (once you've unlocked the gateway at the other end), however it can get confusing since there is no in game map for the area.

Here is a map of the area to help orientate yourself.

If you want further guidance, look here to see where each of those portals lead.

This is my first attempt at a guide, so I hope you find it helpful.