Yes. There are basics of penetrating , here i will show you some of them :
1.You need a tank that can penetrate (Not MG Tanks)
2.You will need APCR(Armor Penetrating Composite Rigid) Rounds.
3. Preferably , you will need to come from the side too.. (eg : If it took 4 shots from the front , it will only take two or 3 shots from the side.)
4. Keep in Mind that Try to hit the armor where it is nearly straight to keep shots from deflecting and be able to penetrate! (see diagram below)


A small Penetrating Diagram (Created from MS Paint)

1.Try to aim for its Tracks (Not the turret/gun mount)
2.Be sure that you have the right tank (Don't go one o' One against a Pershing or IS-2 with a Panzer Ausf. A!)
3.Have APCR Rounds Equipped! HE Wont do any much damage to tanks (Might not even pen anything about M2A2 , Panzer.1 and T-38 .
4.Try to Ambush them , or attack them first.
5.Please know the enemy's armor values , they will come in handy when you encounter a Heavier tank.
The Official RETO-MOTO Tank Statistics and Gun Penetration Value Guide:
http://forum.heroesandgenerals.com/viewtopic.php?f=55&t=14499
(Credits go to Heroes and Generals Official Forums)
More Help at :
http://forum.heroesandgenerals.com/viewtopic.php?f=55&t=13635 (Credit's for this go to TTA : Tank Training Academy Officially and unofficially)
Foolish of me to forget about the "Gunner" Badge.
'Gunner Badge' : A badge that is unlocked through progress down the "Armor Damage" [Ribbon This badge allows you to reload your cannon /Main Gun of tanks to reload faster , giving you the chance to destroy enemy armor quickly and without taking much damage (Remember? The one who fires first has the Advantage.).
To Unlock (Grind , as many people say) this badge , you will need to Damage or Destroy the enemy tanks with your cannon (M2A2 , Panzer Ausf.A or T38 Dont have a cannon , but have a Main Mg , using these to destroy enemy armor won't help in unlocking the gunner badge), you will need the tier 2 tank ([Panzer Ausf.C if you are Germany , M5A1 Stuart if you are America and T26 If you are Soviet Union tanker.) .

Before i start , let me tell you what are these "Soft vehicle's".
Soft Vehicle's: Soft vehicle's are vehicle's used by Infantry for Transport and support purpose (e.g Motor-Bikes , Terrain Vehicles[Jeep , kubelwagen etc.] and APC's [Like Half-tracks , SdKfz)
The vehicle's are lightly Armored (Very Lightly) and Can(yes Can) Be Penetrated By Normal infantry weapons like rifle's , Sub-Machine Gun's if shot's are placed on them.

They offer very little protection from gunfire and Shells.

And easy strategy to kill a Soft Vehicle is to Use HE(High Explosive) on its top , this will not damage the vehicle but kill anyone who is inside it , and give your team another vehicle (if they lack drivers)
that they can use.(This works great with Jeep and Kubelwagen)

For Motorbike's or bikes : Use HE Rounds , you will need to shoot it next to the vehicle (not on it) in order to kill the enemy Troops on it.

For APC's : This time , the vehicle is too much protected against a HE round that it may barely damage anyone in it , this time , you will need to hit it directly with a AP(Armor Piercing) or a APCR(Armor Piercing Composite Rigid) Round in order to Destroy it.(Note it may take more than one cannon shot to kill it.)


If you have the MG Tanks (A.K.A Tankette) , You don't have a cannon , but the ability to rapid fire , to decrease the threat of it getting near you and Using AT weapons and mine's , be sure you follow the following process:

Shooting Card
Shoot the Driver first.(A killed driver means that the vehicle is unable to move.)

The Machine-Gunner Second.(Machine Guns have the ability to damage any tankette , so It is a big threat as for now.)

Dismounted Passengers Third.(Who knows they may be carrying Anti-Tank weapons and may come for revenge of their killed friend(s))
Mounted Passengers Lastly.(They are no threat until one shows bravery and mounts the machine-gun , they are to be regarded as last priority).

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• First Uploaded on 24 May 2015.

• Edited the Checklist's and Created the Soft Vehicle's Section on 31 May 2015.

• Removed Iron Fist Badge Description from Checklist's Section on 1 November 2015.Special Thanks to viewers to Point it out.