This Reshade profile requires Fallout4 to be using TAA (Temporal Anti-Aliasing), otherwise the picture will be awful. You don't need the high-resolution texture pack to be using this but it would be of more use for it!
You will know if reshade is working when your game starts up fullscreen and theres grey/white text in the top-left corner, and any warning about loading shaders is nothing to worry about but something that comes from the types of files installed by Fallout4.
(Updated non-dof file to work properly again)

Reshade is an highly compatible tool that adds graphical effects to games; I used this to try to only enhance the game's look and color but not change them.
Please view these at full size, it's necessary, and now let's show you some images!
First with Depth of Field on:










Depth of field effect settings downloaded and recoded by me into Reshde 3.0 series are from Mika999 http://www.nexusmods.com/fallout4/mods/12302/?


And without DOF effect:

Profile 1 with Depth of Field effect (can be 15fps hit):
https://www.dropbox.com/s/x9hxria6g8y930y/Fallout4%20DOF%20-%20RS3.7z?dl=0

Profile 2 without Depth of Field effect:
https://www.dropbox.com/s/z8x4nv4s6londkq/Fallout4%20-%20RS3.7z?dl=0

!INSTALLATION!: Open archive, extract the folder 'reshade-shaders', Profile1.ini, dxgi.dll, and reshade.ini / dxgi.ini into your FO4 Folder - \steamapps\common\Fallout 4 - and that is all for it too work. If there is any problems with it running, it is NOT related to this installation but most likely a software conflict with other overlay programs, operating system, or anti-virus/malware software.

*Performance adjustments made

I hope you are pleased with the results enough to 'favorite' this and 'rate up'. Thank you and here's some other Reshade Steam Guides I've done for other games:

https://steamhost.cn/steamcommunity_com/sharedfiles/filedetails/?id=1326405244
https://steamhost.cn/steamcommunity_com/sharedfiles/filedetails/?id=751216242
https://steamhost.cn/steamcommunity_com/sharedfiles/filedetails/?id=1097861142
https://steamhost.cn/steamcommunity_com/sharedfiles/filedetails/?id=1141128285
https://steamhost.cn/steamcommunity_com/sharedfiles/filedetails/?id=825422834
https://steamhost.cn/steamcommunity_com/sharedfiles/filedetails/?id=1584033854