SOME SPOILERS FOR HORIZON ZERO DAWN IN CASE YOU STILL HAVEN'T PLAYED IT!
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Ok so the FARO robotics plague would be a perfect scenario to make. It deffinetly wiped out the world. Project Zero Dawn was the "Cure". You're playing to change history and kill humanity before Elisabet can complete Gia. There's a lot to play with here in terms of different ablilites and transmisions e.g unlocking the bigger badder bots, upgrading hacking protocols, updating combat measures, ect. There could even be multiple victory conditions like total erradication of life or turning Hades against Gia or just shutting down project zero dawn. I feel like there's so much potential here for a great time but I don't know how to make a custom scenario atm. Maybe i can learn it and give it a go myself but otherwise i thought I'd toss it out here for any real talent to get their hands on this ;D. Feel free to reply with you're own ideas about this HZD senerio!