The Binding of Isaac: Rebirth

The Binding of Isaac: Rebirth

Binding of Isaac - Afterbirth+ Workshop
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Game often pauses, loading something and crashing
All of the above is long time problem already. I'm making a huuuuuge mod about respriting everything and changing alll of the music and some sounds as well. Everything goes smoothly, but the game can randomly put itself on pause and I see my cursor load ing something. Sometimes game freezes for around 15 seconds. All of this happens with absolutely no reason, because the game usually plays normally. I changed some animations, but I never coded anything anywhere, and my respriting mod is the only mod I use. Why does that happen?
Is it just because the mods itself is turned on? I don't want to lose so much time of my life making this mod, and then being unable to play it without game crashes.
If anyone knows what might be causing this, please, tell me