Seems like several per Discord, City Hall was the big one for me.

I removed/unsubscribed from all the mods i had in the workshop and still cannot load a production queue when i start a new game.

Same issue here.
City hall / wonder panel / global relation panel don't prevent the game to launch but don't work anymore.
Others like non-sticky mouse are so broken that you can't even start a game, the loading screen stays forever.

Yup, it sarteed ok, until no production menu would show. Fail.