here is bunch of unique ideas for you:
idea for addict: gain randm temporary stat similiar to red stew when you eat a pill
idea for moth: gain speed up, dmg up, tears up when you are near a light source like fire+ effect of luna
idea for colector: gain a pocket item called card album which can store endless amount of 3 types of card + smelted ace of spades + your effects
idea for butterfly: rainbow poop spawns more often,flight, tears have chance small luck affected chance to inflict charm, rotten tomato effect, fear, poison or freeze effect
idea for inkling: your effects + you gain tears up depending on how much ammo you have
idea for ness: you have one more ludo tear that is unconected to main one and can be stopped using ctrl/drop key and your shots inflict fire debuf( PK fire refrence)
idea for tness: you can dash like with mars but when you do it you shoot lot of splitting homing blue lasers in close radius(refrence to PK thunder in ssb)
idea for remiel : your effect +you spawn a punching bag familiar that you have to protect. if you beat the room without pb geting hit you get a reward
idea for tremiel: your effect + when you kill an enemy there is 10% chance to spawn friendly imp that stays between rooms but not floors
idea for caasi: every item has a chance to become 1 quality higher or become glich item
idea for tcaasi: you have 2 less slots but if you colect prieviously uncolected item there is a chance to get it pernamently instead of having it in slots+ smelts your items in 2 last slots into pernament
gaia: chance to poison /charm enemies+ when enemy dies due to poison or things other than your atacks they have to drop a flower that heals you, gives you one charge and gives you random pickup
idea for tgaia : chance to red tomato or poison enemies + fires and some enemies turn into flowers
those all are of my ideas. hope you'll enjoy them! Aslo sorry for bad grammar, im not a native english speaker.