I play as Aragon and I wanted to explore my possibilities. I culture switched to Piedmont, formed Sardinia-Piedmont and got those juicy CCR mission, great. After that I formed Italy and to my suprise I still had piedemomtese missions. Picking a "Use Europa Extended missions instead of paradox" did not change anything.

I loaded earlier save and tired with Tuscany and the same thing happened, got Tuscan missions but after forming Italy no Italian missions.

Forming Italy straight from Aragon yelded me Italian missions even without choosing this EE decision. Same thing after forming Spain