Thank you for documenting the Lunatic mode changes in one place. I have some suggestions for other items in the mode:

Rainbow Dragon Badge - Impact damage 40 + 1000% -> 0 + 200%. The item is way more fun when things survive the first hit, plus I think the knockback magnitude should be increased anyway (20 -> 40 seemed to work).

Prismriver instruments - Reduce duration so there is some downtime between uses. Or don't have a Lunatic change but switch them to a 1 bar charge.

Peerless Elixir - Reduce use count by 1 per floor instead of going to 0, buff still goes away completely. Seems kind of ugly to script but it would make you think about when to use it more than once per floor.

Buddha's Bowl - Limit to 3 triggers per room.

Tengu Camera - I had freeze time down to 60 and it was still useful. Makes it a bit harder to milk rewards as well. Not a big deal though.

Broken Amulet - Reduce luck factor in damage, maybe increase the -luck at the same time? Currently it's 55% damage at -3 luck, maybe it could nominally be 30% like the old Godhead.