Log saved for after quitting the run:

22:04:03.186 INFO core.CardCrawlGame> Shutting down publisher integrations...
2022-05-16 18:04:03,191 FileSaver ERROR An exception occurred processing Appender Console org.apache.logging.log4j.core.appender.AppenderLoggingException: java.lang.Error: Interrupted attempt to acquire write lock
at org.apache.logging.log4j.core.config.AppenderControl.tryCallAppender(AppenderControl.java:165)
at org.apache.logging.log4j.core.config.AppenderControl.callAppender0(AppenderControl.java:134)
at org.apache.logging.log4j.core.config.AppenderControl.callAppenderPreventRecursion(AppenderControl.java:125)
at org.apache.logging.log4j.core.config.AppenderControl.callAppender(AppenderControl.java:89)
at org.apache.logging.log4j.core.config.LoggerConfig.callAppenders(LoggerConfig.java:542)
at org.apache.logging.log4j.core.config.LoggerConfig.processLogEvent(LoggerConfig.java:500)
at org.apache.logging.log4j.core.config.LoggerConfig.log(LoggerConfig.java:483)
at org.apache.logging.log4j.core.config.LoggerConfig.log(LoggerConfig.java:417)
at org.apache.logging.log4j.core.config.AwaitCompletionReliabilityStrategy.log(AwaitCompletionReliabilityStrategy.java:82)
at org.apache.logging.log4j.core.Logger.log(Logger.java:161)
at org.apache.logging.log4j.spi.AbstractLogger.tryLogMessage(AbstractLogger.java:2205)
at org.apache.logging.log4j.spi.AbstractLogger.logMessageTrackRecursion(AbstractLogger.java:2159)
at org.apache.logging.log4j.spi.AbstractLogger.logMessageSafely(AbstractLogger.java:2142)
at org.apache.logging.log4j.spi.AbstractLogger.logMessage(AbstractLogger.java:2017)
at org.apache.logging.log4j.spi.AbstractLogger.logIfEnabled(AbstractLogger.java:1983)
at org.apache.logging.log4j.spi.AbstractLogger.info(AbstractLogger.java:1320)
at com.megacrit.cardcrawl.helpers.FileSaver.run(FileSaver.java:31)
at java.lang.Thread.run(Thread.java:748)
Caused by: java.lang.Error: Interrupted attempt to acquire write lock
at javax.swing.text.AbstractDocument.writeLock(AbstractDocument.java:1349)
at javax.swing.text.AbstractDocument.insertString(AbstractDocument.java:701)
at javax.swing.text.PlainDocument.insertString(PlainDocument.java:130)
at com.evacipated.cardcrawl.modthespire.ui.MessageConsole$ConsoleOutputStream.clearBuffer(MessageConsole.java:226)
at com.evacipated.cardcrawl.modthespire.ui.MessageConsole$ConsoleOutputStream.handleAppend(MessageConsole.java:183)
at com.evacipated.cardcrawl.modthespire.ui.MessageConsole$ConsoleOutputStream.flush(MessageConsole.java:154)
at java.io.PrintStream.write(PrintStream.java:482)
at org.apache.logging.log4j.core.util.CloseShieldOutputStream.write(CloseShieldOutputStream.java:53)
at org.apache.logging.log4j.core.appender.OutputStreamManager.writeToDestination(OutputStreamManager.java:250)
at org.apache.logging.log4j.core.appender.OutputStreamManager.flushBuffer(OutputStreamManager.java:283)
at org.apache.logging.log4j.core.appender.OutputStreamManager.flush(OutputStreamManager.java:294)
at org.apache.logging.log4j.core.appender.AbstractOutputStreamAppender.directEncodeEvent(AbstractOutputStreamAppender.java:199)
at org.apache.logging.log4j.core.appender.AbstractOutputStreamAppender.tryAppend(AbstractOutputStreamAppender.java:190)
at org.apache.logging.log4j.core.appender.AbstractOutputStreamAppender.append(AbstractOutputStreamAppender.java:181)
at org.apache.logging.log4j.core.config.AppenderControl.tryCallAppender(AppenderControl.java:161)
... 17 more

22:04:03.209 INFO steam.SteamTicker> [ERROR] SteamAPI stopped running.
22:04:03.278 INFO core.CardCrawlGame> Flushing logs to disk. Clean shutdown successful.
Game closed.

also getting this issue

I got it again. Act one, first event ... no idea what's causing it.
https://i.ibb.co/K61RpfR/Slay-the-Spire-Corrupt-the-Spire-event.png

Thanks for reporting this. Unfortunately, the log you posted only has all the stuff for saving and exiting from a run, so it doesn't help with figuring this out.

What other mods did you have on when you encountered this? I haven't been able to reproduce this, and the most likely reason is because it's caused by Corrupt the Spire interacting with some other mod. I see that you have 138 mods running, so it may be hard to narrow this down.

I do have a guess about what could cause this, so even if I can't reproduce this, I'll add some logging and checks that try to catch empty events (which is what you seem to be getting in the screenshot).

The next time I get this, I'm going to take a copy/paste of the ENTIRE log.
Guess we'll have to wait for the next time to get this one fixed properly.