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White Pony: Holy Light beams also ignite enemies.
Crack the Sky: Holy Light beams ignite enemies, and every enemy killed by a beam grants a small temporary damage up.
Bob's Rotten Head: Periodically creates Bird's Eye fires as it travels, before leaving a Hot Bombs fire after landing.
Book of Secrets: While held, a large "beam" of shadow spawns in the center of the Secret and Super Secret Rooms, which grant half a black heart and a +0.5 damage up for the floor upon contact.
Book of Shadows: While active, enemies that come into contact with Isaac ignite.
Converter: If the converted heart was a black heart, grants a permanent +0.5 damage up.
Crystal Ball: When Crystal Ball would normally drop a soul heart, it drops a black heart instead.
Fortune Cookie: When Fortune Cookie would normally drop a soul heart, it has a 33% chance to spawn a black heart instead. If a fortune is created instead, a small temporary damage up is granted.
D10: A small temporary damage up is granted for every enemy rerolled, and a slightly larger temporary damage up is granted for every enemy removed by being rerolled.
D100 and D4: Rerolled passive items have a small chance to instead be rerolled into Pentagram, even if the item in question was not in a pool that holds it. This can grant multiple Pentagrams.
Dad's Key: Bird's Eye fires shoot out of every opened door.
Dead Sea Scrolls: Berserk!, Sulfur, Dark Arts, Gello, Book of the Dead and Lemegeton are added to the possible activated items.
Best Friend: Best Friend shoots out Bird's Eye flames in a hexagonal shape after it explodes.
Mom's Pad: Enemies with the fear debuff take 50% more damage while the effect is active.
Mom's Bra: Enemies with the petrified debuff take 50% more damage while the effect is active.
Monster Manual: Spawned familiars are more likely to be taken from the Devil Item Pool, and familiars spawned from there are spawned twice when they do spawn.
Monstro's Tooth: Monstro II spawns instead, dropping from the ceiling on a foe before firing a Brimstone beam at the nearest foe.
Red Candle, Blue Candle: Gives a small, temporary damage up for every enemy killed by the created fire. The damage up should subside by the time its cooldown has elapsed.
Remote Detonator: Detonated bombs create a line of fiery tears between Isaac and them upon detonation.
Satanic Bible: Devil Deal spawned in the Boss Room switches between the rolled item and Pentagram, like Tainted Isaac. Only one can be taken.
Shoop Da Whoop: Beam becomes a dark red color, deals 3x tear damage instead of x2 and gains most of regular Brimstone's synergies.
The Bean: Ignites enemies in addition to poisoning them.
The Bible: Isaac has demonic wings rather than angelic ones, and creates a trail of fire trailing closely behind him while the flight is active.
The Boomerang: Petrified enemies take 50% more damage.
The Gamekid: If Isaac's health is full, killed enemies have a chance of giving him half a black heart when killed.
The Hourglass: Slowed enemies take 30% more damage.
The Nail: Isaac gains +0.18 speed rather than a speed reduction, and destroyed grid objects have a chance to spawn a Bird's Eye fire or drop half a black heart.
The Pinking Shears: Isaac's body destroys projectiles it moves through in a fashion similar to Dark Arts, alongside gaining a dark appearance similar to Tainted Judas. Enemies that the body familiar contacts ignite.
The Poop: The poop spawned has a very high chance to turn into a black poop.
Unicorn Stump: Enemies that contact Isaac ignite.
Yum Heart: Grants a temporary damage up that increases with the number of heart containers Isaac has.
D8: Reroll formula is changed such that the damage stat never goes below the value it was before the item was used, always resulting in an increased damage stat.
Diplopia: The copied item(s) switch between the original item and Pentagram, like Tainted Isaac.
Friendly Ball: After capturing an enemy, the ball explodes like a bomb, dealing 100 damage and leaving a Hot Bombs fire.
Glowing Hourglass: Grants Isaac a damage up until he clears another room.
Mega Blast: Mega Blast lasts an additional 6.66 seconds.
Mine Crafter: The planted TNT barrel creates a burst of Bird's Eye flames in a hexagonal shape after detonating.
Black Hole: The hole takes on a red-and-black appearance, deals 1 damage a tick and ignites enemies. Enemies killed by the Black Hole have a chance to spawn Ocular Rift effects.
Brown Nugget: Tears fired by Brown Nugget flies deal 6.66 damage and have a chance to inflict bleeding or ignite enemies.
Book of the Dead: Created enemies are Red Champions.
Coupon: Devil Deal items made free alternate between them and Pentagram, like Tainted Isaac. Items on sale are reduced to 6 cents rather than 7.
Crooked Penny: Duplicated items alternate between them and Pentagram, like Tainted Isaac. On a failure, a temporary damage up is given for every pickup and item destroyed.
Dull Razor: All enemies in a large radius near Isaac take a moderate amount of damage and gain the bleeding debuff when Isaac uses Dull Razor.
Eden's Soul: Spawned items alternate between themselves and Pentagram, like Tainted Isaac. Additionally, after use, grants a damage up for the floor.
Sharp Straw: Enemies have a chance to drop black hearts.
Smelter: Grants a small, permanent damage up whenever Isaac smelts a trinket.
Telekinesis: Reflected projectiles ignite enemies and inflict bleeding.
Void: Favors damage upgrades when assigning stat upgrades. When voiding items from the Angel Room Pool, grants a damage up in addition to two other stat upgrades.
Anima Sola: Chained enemies are ignited and take 50% more damage.
Berserk!: Isaac gains an aura that ignites enemies around him. Strikes with the melee weapon from Berserk! have a chance to inflict bleeding.
Eraser: Whenever an erased enemy would spawn, Isaac instead gains a substantial temporary damage up.
Friend Finder: Spawned enemies are made into Red Champions, if possible.
Gello: Gello gains a dark, Azazel-like appearance, and it holds a Dark Arts knife, which it throws while firing similarly to Mom's Knife alongside regular tears.
Keeper's Box: Items spawned by Keeper's Box have a chance to be from the Curse Room Pool instead of the Shop Pool.
Lemegeton: Lemegeton wisps act like Book of Belial wisps, firing their projectiles.
Plum Flute: Baby Plum deals 15 damage per tick via contact damage, 6.66 damage per shot, and 3.33 damage per tick with their creep.
Suplex!: The created rock wave also ignites enemies, and a trail of Bird's Eye fires are created as Isaac dashes forward.