^ = Includes upgrades that retain the original effect

- Sprintmaster + Non-bundle balloons = Higher jump speed
- Sprintmaster +Bundled balloons = Even higher jump speed (Doesn't stack with non-bundled balloons)
- Sprintmaster + Incomplete frog gear = Less air friction
- Sprintmaster + Frog Gear = No air friction
- Sprintmaster + Pre-Lightning Boots sprinting boots = Slight sprint increase
- Sprintmaster + Lightning Boots^ = Major sprint increase

- Grubbysong + Grubbyfly's Elegy = Increases mana gained when hit by 20
- Grubbysong + Band of Starpower^ = Increases mana gained when hit by 10 (Overridden by Magic Cuffs synergy)
- Grubbysong + Magic Cuffs^ = Increases mana gained when hit by 20

- Creeper Cocoon + Avenger Emblem^ = Creeperlings deal 5x more damage
- Creeper Cocoon + Pygmy Necklace = You gain one extra creeperling
- Creeper Cocoon + Yoyo String^ = Creepers have a 1/3 chance of webbing enemies, slowing their horizontal movement to 80% (Does not work on enemies that don't take knockback, bosses, or non-attackable NPCs)
- Creeper Cocoon + Sprintmaster = Creeperling launch speed is increased by 50%
- Creeper Cocoon + Grubbysong = Creeperlings give the player 2 mana each time they hit an enemy

- Thorns of Agony + Magma Stone^ = Thorns now inflict "Hellfire"
- Thorns of Agony + Spore Sac = Spew spores when taking damage
- Thorns of Agony + Flesh Knuckles^ = Thorns deal double damage & gives you Wrath for 5 seconds
- Thorns of Agony + Panic Necklace^ = Leave behind small thorns while with Panic! effect
- Thorns of Agony + Honey Comb^ = Make giant bees swarm when taking damage

- Granite Shell + Any Shield (except OOA Shields) = Increases amount of hits shell can take. Depends on shield type:
Ankh Shield > Frozen Shell = Hero Shield = Paladin Shield > Cobalt Shield = Obsidian Shield = Shield of Cthulhu
- Granite Shell + Band of Regeneration^ = Doubles band regeneration speed when shield is active
- Granite Shell + Putrid Scent = Releases a gas cloud upon breaking

- Mark of Pride + Yoyo Glove^ = Throw out an extra third yo-yo when hitting an enemy
- Mark of Pride + Pygmy Necklace = Gives you an extra minion slot
- Mark of Pride + Magic Quiver = Shoots a bonus arrow when using a bow weapon
- Mark of Pride + Mana Flower = Reduces mana cost by 20%

- Defender's Crest + Stink Potion (Secret Combo) = Makes odor deal double damage
- Defender's Crest + Panic Necklace^ = Spews a powerful odor when hurt
- Defender's Crest + Lucky Horseshoe^ = Odor has a chance of being a "lucky odor"

- Grubbyfly's Elegy + Fury of the Fallen = Allows powered-up holy slashes to be shot when below 25% HP
- Grubbyfly's Elegy + Mark of Pride = Increases size of holy slashes
- Grubbyfly's Elegy + Rifle Scope^ = Increases range of holy slashes

- Fury of the Fallen + Moon Shell^ = Transforms user into werewolf when below 25% HP (Werewolf stats are amplified even further during the night)
- Fury of the Fallen + Magma Stone^ = Inflicts "Oiled" upon struck enemies for 6 seconds when below 25% HP
- Fury of the Fallen + Frozen Turtle Shell^ = Inflicts "Frostburn" upon struck enemies for 3 seconds when below 25% HP
- Fury of the Fallen + Rifle Scope^ = Increases crit of ranged weapons
- Fury of the Fallen + Eye of the Golem^ = Increases crit of all weapons by 10%
- Fury of the Fallen + Vitamins^ = Fury is now activated when at full HP

- Dashmaster + Sprintmaster = Increases walking speed by an extra +10%
- Dashmaster + Soaring Insignia = Allows you to dash upward
- Dashmaster + Tabi^ = Dash travels twice as far in all directions
- Dashmaster + Rocket Boots^ = Double tapping upward with remaining rocket time launches you up in the air. Can only be used once per flight and uses up rocket time
- Dashmaster + Avenger Emblem^ = Dash deals heavy contact damage, gives you damage reduction, and prevents knockback

- Spore Shroom + Defender's Crest = Replaces spore cloud with a deadlier fart cloud
- Spore Shroom + Honey Comb^ = Spew bees when healing
- Spore Shroom + Star Cloak^ = Make stars fall when healing

- Hive Blood + Bezoar^ = Poison nearby enemies when Potion Sickness is inactive
- Hive Blood + Honey Comb^ = Friendly bees heal 1 HP when hitting an enemy (cooldown of 10 ticks each hit and also giant bees heal 2 HP)

- Nestron + Defender's Crest = Baby sharkrons become Fartrons and explode into fart clouds (stacks with Buzzrons)
- Nestron + Honey Comb = Baby sharkrons become Buzzrons and explode into friendly bees (stacks with Fartrons)

- Glowing Womb + Defender's Crest = Fairies deal less damage but leave behind fart clouds upon detonation
- Glowing Womb + Fury of the Fallen = Fairies deal 50% more damage while player is below 25% HP
- Glowing Womb + Nature's Gift^ = Fairies use 25% less mana
- Glowing Womb + Band of Starpower^ = 2 more fairies can be active at a time
- Glowing Womb + Fast Clock = Fairies spawn 2x faster (Also decreases mana regen delay)

- Soul Eater + Power Glove^ = Increases mana gained when striking enemies with a true melee attack to 30, and makes amount vary with damage with a melee projectile
- Soul Eater + Magic Quiver^ = Increases mana gained when striking enemies with an arrow to 10
- Soul Eater + Necromantic Scroll^ = Increases mana gained when striking enemies with a minion/summon projectile by 20
- Soul Eater + Sharktooth Necklace^ = Increases mana gained when striking enemies with a non-magic weapon by 10