Tainted Samson - Berserker Baby
"He often goes on a rampage!"
Effect:A familiar that does nothing but gains rage from damage dealt to enemies or the player.
With enough rage,Berserker Baby will perform a slam attack on a random enemy,and will use a his bone to smash other enemies! Slam attacks will send down rocks from above!
Item Pool:Devil Deal(Normal + Greed,1 heart cost),Ultra Secret(Weight 0.5)
Quality:3

Tainted Bethany - The Four Humors
"a dozen leaches needed"
Effect: upon being picked up and going to the next room (after being hit) get one of 4 effects.
Deep Red (blood): For every full red heart(3 soul hearts) you have gain +1.5 damage up
Bright Yellow (Yellow Bile): every 8th tear fired (10 seconds when charging) fire a tiny monstro's lung attack. Non boss Enemies kill by it spawn a random poop.
Black (Black Bile): your current tear rate (when the effect is activated) now represents the chance for a black heart to replace any heart.
White (Phlegm):Upon killing an enemy they will spawn a small white creep that will confuse enemies that walk on it. (lasts 5 seconds)
When you get hit the effect is removed and 2-5 small leeches
(hidden synergy: if you have leech the item the small leeches will be friendly)
Quality: 3
Item pool: Devil ( Normal + greed, 2 heart cost), Secret. (Weight .5)

Eden - Forbidden Fruit
"One bite doesn't hurt."
Similar to Eden's Blessing, but instead you get a glitched item at the start of your next run and you are guaranteed a tier 3 or tier 4 item the next time you play as Eden.

Azazel - Hellstone
"One step closer to Zenith."
Charges up a fireball that when spit on impact it causes a diagonal or cardinal fire spread.
If paired with Brimstone, instead of a laser or fireball it becomes a wave of molten lava spat from your mouth.

Tainted Cain - Bloody Stone
"Forever Cursed."
Every floor onward will always have a curse, it may also have a chance of the curse being curse of the cursed, but you gain a benefit depending on the curse for the entire floor:
Curse of the Blind: Items won't be tier 0 or 1.
Curse of Darkness: You gain a fear aura.
Curse of The Lost: You gain flight and spectral tears.
Curse of the Maze: You have a high chance teleporting to a special room or secret room instead.
Curse of the Unknown: You take half damage and hearts become more common.
Curse of the Labyrinth: You'll gain the effects of More Options, Even More Options, and Options?
Curse of the Cursed: You gain Holy Mantle.