I've been slogging through it for about 15 hours and have some more bugs to add:
* You cannot build the initial research table/bench/whatever to start the tech tree. - Maybe you're supposed to find one in the wild to use but this seems like a design fail as you can't even research the survival skills which seem to be the basic game progression you would start with. (To explain, rather than quitting here, I used Shift + F12 to place a bench so that I could still play.)
* Many combat animations are broken - characters will glitch when it is their turn to attack and wave their arms before their opponent attacks again and again and again. Often the character with less bugged weapon animations wins.
* Misplaced wall in the Hub - blocks an area off, pretty self explanatory
* The Super shopper event seems bugged - A guy just shows up, shouts a bit and then runs off. Has happened 3 times.
* The tech resource benches will eat any resources you try to manually put into them without filling. Characters can still use them automatedly.
* Ale distillery uses wheatstraw instead of barleystraw as the tech would indicate. No use for barley straw as a result.

The game is super slow compared to the base game, load times are routinely longer than 30 seconds even when just switching biomes. This is with the reduced textures and not using the no despawn mods.

Might update as I find more bugs