New Game+ breaks the game, let me explain.
So, I use an autoclicker named Cookie Assistant, alongside Magic Regen Tweak, Mod Menu Tweaks, Buff Timer Tweaked, EMHU, MHUR, Max Buy Button Restorer, Smooth Render and CCSE.

The first thing I noticed is that the Max Buy button breaks and I am unable to use it (probably because it doesn't account for the 1.35x increase opposed to the 1.15x increase), the visuals break and I am unable to reasonably play the game (during New Game+) due to the cookie counter and various elements freezing repeatedly even when I restart the game over and over.

There are also non-autoclicking related fps issues that freeze the game on occasion, especially before New Game+. While turning off autoclicking helps, it doesn't seem to be the issue behind it and I have to eventually close and re-open the game on repeated intervals. The specifics behind the fps issue is that it has light stutters at first, and eventually starts slowing to a crawl below 30 fps and freezes repeatedly until it is permafrozen. So this isn't an issue on the fps mod's part, either.