Just did 1 run of this and Awsome mod! couple things I recommend
Please don't abbreviate Dammage Reduction to DR as I got Confused and had to look up what it ment.

Have the Hearts increase as your hp goes up by 20 life so its easier to gage

Add classes to the runs such as melee, summoner, Ranger, and Mage so its more fun to pick and choose items for your runs

Try to Use armor/accesory slots to your advantage in making this as you could alongside the passive items every room to have enemys have a low chance to drop armor.

PLEASE allow you to upgrade weapons to add variety to the runs