Also on Mac OS 10.11, with somewhat similar problems.

First this is an excellent mod! Probably the best restructure of a previous somewhat lackluster game I have played!

But I have had some problems....

1) Tried to install the mod on the App store version, after some trial and error I got it start but could not get the terrain to display.

2) Got the steam version as well. Got the mod to start and play if I did the following, and do it every time I load the save game (do not work in App store version).
a) Delete all game cache files.
b) Restart Steam client.
c) Only use the Codex v. 7 mod, none of the sub-modules.

The game froze/crashed if I did something of the following:
* Met another civilization, triggering the diplomacy screen.
* Chose to research the last non-endgame technology.
* Chose the "strength against aliens" virtue in the beginning of the Might tree.
* Started with a worker and got an extra worker from a virtue.
* Occasional without explanation.

Other things:
At the end game I was not able to start the Mindflower project (my big favorite).
Every time I reload the game the Commonwealth and Moonbase achievements are reset, making those ways hard to walk. The first 50 or so rounds a reload also makes loads of leeches respawn, sometime eradicating cities.

Probably a combination of lots of things, Mac OS might being one.
I play with weird game settings in a "me vs aliens solitary mode" to avoid making contact with another civs and crash.
Settings are
1 AI civilization, next biggest planet
Lush
winning: Domination and Trancendance
To speed up game: legendary start, no charge limit workers, no army limit, +20 vitality, no other special settings.

Have not given up, made 30-40 restarts so far trying to find a possible playable solution. Next will be on small planet without any "special game settings".

I ran into a similar error. I'm also on Mac (10.15.4 Catalina).

I would hit errors that immediately exit the game client (go to the desktop). In one game (standard speed with doubled virtue/tech cost) I had errors at turn ~71. Somehow reloading and replaying it would sometimes not crash... but then crash on later turns. I got up to turn 80 by the time I posted this.

The Database.log file ends with this. Perhaps there is a call to a database for something regarding Affinities:


A search of Lua.log didn't turn up any lines with the text 'error' in them.... Hmmm! the investigation continues