My idea was to just throw all of them into a server config like my starter bag mod which will let you toggle all the artifacts individually. Now that I have a chance to contribute to Risk of Terrain though I'll have to reconsider my options
That said, later today I'll most likely be updating this mod with the Mod NPC effect toggle as well as an icon that shows above each affected NPC's head so you can tell when the mod actually does something

Dude, this idea is actually amazing.
I haven't tried it yet.
But if you do add more Artifacts, may I suggest a separate slot just for artifacts?
Adding another layer of playstyle customization to Terraria has always been what the best mods do best.

Will do, thanks for the offer

Hey! I’m the owner of the mod you linked. Number one, thanks for linking it, I really appreciate! Number two, if you’re still interested in working on artifacts, we actually haven’t implemented them all yet, and a few were broken by the change to 1.4.4. If you are interested, you can dm me on discord at @fryguythe777th and I will confer with the other devs to make sure you’ll be good to join the team.

Originally I planned to create more Risk of Rain 2 artifacts as Terraria mods, and then I had the idea to put them all into one big mod, until I realized there are some RoR mods out there already. I'm going to leave this mod as it is, because I find it quite humorous, but I also recommend Risk of Rain for 1.4.4 .