after some time in game (0.5-2 hours) i start to get massive problems with water consumption, energy usage, garbage accumulation (they increase 3-4 times). Once it happens mod options are inaccessible through settings (tab "realistic population 2" is there but, once you click it, nothing loads). Also "realistic population" button, available on building info screen disappears. Issue goes away after relaunching the game(going to main menu and reloading saves does not help), and reoccurs after some time in game.
I use legacy calculations for buildings that i have problems with.