I would like to share this here, I have an idea to change the Depression moodle for "Miserable".
Since it doesn't make sense to cure "Depression" by reading comic books and eating chocolate.

When you are Miserable you'd have a chance to catch actual Depression every in-game hour, if that happens, the Depression couldn't be taken away by increasing happiness, it would limit your max happiness (increase unhappiness gain), and Cause Fatigue like in this mod, true Depression could only be treated with Antidepressants, calming it's effects for a while, and it would go away after a couple months of taking the antidepressants constantly, the time it takes to remove depression also gets determined by how well tou maintain the happiness moodle, if it never gets to Miserable for enough time, you'll be more successful, being anxious also plays a part here.
So could having a good diet.
Fulfilling all requirements would allow you to get rid of the depression in a month, but having had depression in the past increases a bit the likelihood percentage of getting Depression again the next time you character becomes Miserable.
(There could be a period of grace after getting out of a depression in which the Miserable moodle wouldn't lead to depression, and this period of time gets larger each time the character gets out of a Depression).