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From wiki:
"If a Secret Room is next to a Challenge Room, it can be entered by using a bomb in the Secret Room on the wall separating the two rooms. However, the entrance to the Secret Room from the Challenge Room closes itself, meaning Isaac cannot escape through the Secret Room entrance.
If Greed or Super Greed spawn in the secret room however, the wall leading to the challenge room will be barred up and cannot be bombed open. The metal bars do not disappear after they are defeated or if the player leaves the room, meaning they can only enter the challenge room the traditional way.
If Isaac bombs into either variation of Challenge Room through a Secret Room and leaves, the bombed entrance will close and must be bombed open again."
Not like boss challenge rooms had consistently good enough rewards to make them only accessible at truly low health lol