First off, as stated in the rulebook it is not in the spirit of the game to get too hung up on the exact rules, as long as everyone is having fun with what you make of them.

However, some people such as myself prefer a little more structure, so I'm collecting people's questions and the author's rule clarifications in this thread. I'll spoiler tag anything about specific boxes as much as I can.

Q: What can I do in the Draw/Play step?
A: You may either Draw 1 card from a Box/Deck you are allowed to, or Play 1 card from your hand. You can play to yourself or to another player, at which point it resolves as if they played it. You must do one of these actions, or an "Instead of..." action.

Q: What is the Explore step?
A: In this step you must take 1 card from the top of any Box/Deck you are allowed to Explore and play it on yourself. This is known as Discovering a card.

Q: How do I know what Boxes/Decks I can draw from?
A: Every box contains an info card stating who can draw from what deck. Everyone can Draw/Play/Explore from the "Basic Box".

Q: When do I play "Play immediately" cards?
A: As soon as you draw it you must play it on yourself.

Q: What's the difference between a Box and a Deck?
A: Boxes always have box in the name and you will be able to do at least one of Draw/Play/Explore. Decks on the other hand will have a special requirement to interact with them be that always exploring them at the end of your turn, discarding a card to explore them, or only exploring them when you win.

Q: Where do cards go once played?
A: Usually to the respective discard pile for their deck unless otherwise stated. If a card (other than an info card) opens a box, it is deleted.

Q: What's the difference between a discard pile and the Junk Pile?
A: Every deck has it's own discard pile, which is reshuffled when that deck runs out. The Junk Pile is communal between decks. To begin with, the Junk Pile is only used when "reducing to your hand limit".

Q: Do goal cards replace other goals?
A: There can be as many goal cards in play as there are players. Then any new goals replace an old goal of your choice. The old goal is discarded.

Q: What does Collecting a Box do?
A: It's another stat for your card.

Q: What happens if I get a box without an info card?
A: You can't use that box until something instructs you to.

Q: Do you have to take ALL "end of turn" actions?
A: Yes, but you get to choose the order.






------Spoiler Zone------








Teams
Q: Can a person be on more than 1 Team?
A: Yes.


"Alchemy Box"
Q: Does the "If the second card doesn't have 2 effects discard it" rule overrule "If discovered"?
A: Yes. It even beats "Play Immediately".


"Dave"
Q: Can Dave's Friend see Dave's hand?
A: Yes, Dave is fully under Dave's Friend's control, hand and all.