A fair bit of warning, the more items on active belts and in machines the more processing time on the client in control of the machines.

To avoid this, try these steps:

Limit the number of items in the machines and on the conveyors
Use boxes at the end of conveyors to take the items off the conveyors
Put production materials in extension drums and towers, especially high number items
Do your production in stages, for example: deconstruct everything first

I hit a slight stutter with thousands of items on many belts and machines, it was probably close to 10,000 items searched per in game minute... excessive to be honest but possible with high volume ammo crafting.